Risk of neoplasms in acromegaly <br>[Polish version: Ryzyko rozwoju nowotworów w akromegalii p. 118]

Marek Ruchała; Ewelina Szczepanek-Parulska; Maciej Fularz; Kosma Woliński

doi:10.5114/wo.2012.28790

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2012
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abstract:

Review paper

Risk of neoplasms in acromegaly
[Polish version: Ryzyko rozwoju nowotworów w akromegalii p. 118]

Marek Ruchała

,

Ewelina Szczepanek-Parulska

,

Maciej Fularz

,

Kosma Woliński

Wspolczesna Onkol 2012; 16 (2): 111–117
[Polish version: Wspolczesna Onkol 2012; 16 (2): 118–124]

DOI: https://doi.org/10.5114/wo.2012.28790

Online publish date: 2012/05/29

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Acromegaly is a chronic disease caused by the excessive secretion of growth hormone (GH), and as a result, of insulin-like growth factor-1 (IGF-1). Untreated, the condition reduces the patients’ life expectancy and leads to a series of complications, among which an increased risk of carcinogenesis is considered most important. This paper is an analysis of the publications on the issue of the formation of neoplasms, both malignant and benign, in acromegalic patients. Although the influence of acromegaly on carcinogenesis remains controversial,

a number of studies indicate that the frequency of developing tumors in this patient group is higher. Moreover, numerous publications particularly stress the increased risk of developing neoplasms in patients who had been untreated for a long period of time and show elevated levels of GH and IGF-1. Consequently, a quick diagnosis and the implementation of effective treatment play

a key role in the management of this disease.

keywords:

Risk of neoplasms in acromegaly [Polish version: Ryzyko rozwoju nowotworów w akromegalii p. 118]

Marek Ruchała , Ewelina Szczepanek-Parulska , Maciej Fularz , Kosma Woliński

neoplasms, cancer, acromegaly, epidemiology

Risk of neoplasms in acromegaly
[Polish version: Ryzyko rozwoju nowotworów w akromegalii p. 118]

Marek Ruchała

,

Ewelina Szczepanek-Parulska

,

Maciej Fularz

,

Kosma Woliński