Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers

Adam Borek; Franciszek Drzymała; Malwina Botor; Aleksandra Auguściak-Duma; Aleksander Sieroń

doi:10.5114/kitp.2019.88601

eISSN: 1897-4252
ISSN: 1731-5530

Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery

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abstract:

Review paper

Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers

Adam Borek

¹

,

Franciszek Drzymała

¹

,

Malwina Botor

¹

,

Aleksandra M. Auguściak-Duma

¹

,

Aleksander L. Sieroń

¹

Department of Molecular Biology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

Kardiochir Torakochir Pol 2019; 16 (3): 124-127

DOI: https://doi.org/10.5114/kitp.2019.88601

Online publish date: 2019/10/28

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AMA

Borek A, Drzymała F, Botor M, Auguściak-Duma AM, Sieroń AL. Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2019;16(3):124-127. doi:10.5114/kitp.2019.88601.

APA

Borek, A., Drzymała, F., Botor, M., Auguściak-Duma, A. M.,  & Sieroń, A. L. (2019). Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 16(3), 124-127. https://doi.org/10.5114/kitp.2019.88601

Chicago

Borek, Adam, Franciszek Drzymała, Malwina Botor, Aleksandra M Auguściak-Duma,  and Aleksander L Sieroń. 2019. "Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 16 (3): 124-127. doi:10.5114/kitp.2019.88601.

Harvard

Borek, A., Drzymała, F., Botor, M., Auguściak-Duma, A.,  and Sieroń, A. (2019). Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 16(3), pp.124-127. https://doi.org/10.5114/kitp.2019.88601

MLA

Borek, Adam et al. "Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers." Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, vol. 16, no. 3, 2019, pp. 124-127. doi:10.5114/kitp.2019.88601.

Vancouver

Borek A, Drzymała F, Botor M, Auguściak-Duma A, Sieroń A. Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2019;16(3):124-127. doi:10.5114/kitp.2019.88601.

PlumX metrics:

Abdominal aortic aneurysm (AAA) is a dangerous condition involving pathological dilation of the aortic wall. Due to the asymptomatic course of this disease and the dangerous consequences of its rupture, it is important to identify its specific bio-markers expressed as early as possible. Different expression profiles of microRNAs (miRNAs) were detected in patients diagnosed with AAA. MicroRNAs are small non-coding RNA molecules that regulate the expression of other genes at the translation stage. miRNAs affecting translation can lead to abnormal remodeling of extracellular matrix, inhibition of the cell cycle, cell aging or intensified inflammation. This review summarizes current knowledge about the role of microRNAs in the context of formation and development of abdominal aorta aneurysm and the possibility of using some miRNAs as bio-markers, and also provides basic information about miRNAs and aneurysms.

keywords:

Roles of microRNAs in abdominal aortic aneurysm pathogenesis and the possibility of their use as biomarkers

Adam Borek 1 , Franciszek Drzymała 1 , Malwina Botor 1 , Aleksandra M. Auguściak-Duma 1 , Aleksander L. Sieroń 1

miRNA, inflammation, matrix metalloproteinases

Adam Borek

¹

,

Franciszek Drzymała

¹

,

Malwina Botor

¹

,

Aleksandra M. Auguściak-Duma

¹

,

Aleksander L. Sieroń

¹