Ser326Cys polymorphism of hOGG1 gene in postmenopausal breast cancer women from the Lodz region of Poland

Anna Sobczuk; Beata Smolarz; Hanna Romanowicz-Makowska; Marek Zadrożny; Jakub Baszczyński; Tomasz Pertyński

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

2/2009
vol. 8

Send email

Copy url:

abstract:

Original paper

Ser326Cys polymorphism of hOGG1 gene in postmenopausal breast cancer women from the Lodz region of Poland

Anna Sobczuk

,

Beata Smolarz

,

Hanna Romanowicz-Makowska

,

Marek Zadrożny

,

Jakub Baszczyński

,

Tomasz Pertyński

Przegląd Menopauzalny 2009; 2: 90-93

Online publish date: 2009/05/11

View full text Get citation

Reduced DNA repair capacity can render a high risk of developing many types of cancer including breast cancer. Polymorphisms in DNA repair genes may contribute the genetic instability and carcinogenesis. In the present work the distribution of genotypes and frequency of alleles of the Ser326Cys polymorphism of the hOGG1 gene in postmenopausal breast cancer women were analysed. Blood samples were obtained from 100 women with breast cancer and control (n = 106). The polymorphisms were determined by PCR-RFLP methods. No association between Ser326Cys polymorphism of hOGG1 and breast cancer risk was observed. The distribution of the genotypes of the Ser326Cys polymorphism in both controls and patients did not differ significantly (p > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences (p > 0.05) in genotype distributions and allele frequencies between subgroups assigned to histological stage. The results suggest that the Ser326Cys polymorphism of the hOGG1 gene may not be linked with appearance and development of breast cancer in women from the Lodz region of Poland.

keywords:

Ser326Cys polymorphism of hOGG1 gene in postmenopausal breast cancer women from the Lodz region of Poland

Anna Sobczuk , Beata Smolarz , Hanna Romanowicz-Makowska , Marek Zadrożny , Jakub Baszczyński , Tomasz Pertyński

breast cancer, gene polymorphism

Anna Sobczuk

,

Beata Smolarz

,

Hanna Romanowicz-Makowska

,

Marek Zadrożny

,

Jakub Baszczyński

,

Tomasz Pertyński