Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis

Mizerska-Wasiak M, Gajewski Ł, Cichoń-Kawa K, et al. Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis. Central European Journal of Immunology. 2018;43(2):162-167. doi:10.5114/ceji.2018.77386.

APA

Mizerska-Wasiak, M., Gajewski, Ł., Cichoń-Kawa, K., Małdyk, J., Dziedzic-Jankowska, K.,  & Leszczyńska, B. et al. (2018). Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis. Central European Journal of Immunology, 43(2), 162-167. https://doi.org/10.5114/ceji.2018.77386

Chicago

Mizerska-Wasiak, Małgorzata, Łukasz Gajewski, Karolina Cichoń-Kawa, Jadwiga Małdyk, Katarzyna Dziedzic-Jankowska, Beata Leszczyńska,  and Agnieszka Rybi-Szumińska et al. 2018. "Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis". Central European Journal of Immunology 43 (2): 162-167. doi:10.5114/ceji.2018.77386.

Harvard

Mizerska-Wasiak, M., Gajewski, Ł., Cichoń-Kawa, K., Małdyk, J., Dziedzic-Jankowska, K., Leszczyńska, B., Rybi-Szumińska, A., Wasilewska, A., Pukajło-Marczyk, A., Zwolińska, D., Bieniaś, B., Sikora, P., Szczepańska, M., Stelmaszczyk-Emmel, A., Górska, E.,  and Pańczyk-Tomaszewska, M. (2018). Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis. Central European Journal of Immunology, 43(2), pp.162-167. https://doi.org/10.5114/ceji.2018.77386

MLA

Mizerska-Wasiak, Małgorzata et al. "Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis." Central European Journal of Immunology, vol. 43, no. 2, 2018, pp. 162-167. doi:10.5114/ceji.2018.77386.

Vancouver

Mizerska-Wasiak M, Gajewski Ł, Cichoń-Kawa K, Małdyk J, Dziedzic-Jankowska K, Leszczyńska B et al. Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis. Central European Journal of Immunology. 2018;43(2):162-167. doi:10.5114/ceji.2018.77386.

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Introduction
GDIgA1 (galactose deficient IgA1) plays a significant role in the pathogenesis of IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSN)

Aim and study
The aim of this study was to assess the relevance of serum GDIgA1 level as a prognostic marker in children with IgAN and HSN.

Material and Methods
41 children were included to the study group (15 IgAN, 26 HSN) and 22 to the control group. The following parameters were evaluated at baseline and endpoint: proteinuria, erythrocyturia, serum creatinine, serum IgA, GFR. A kidney biopsy was performed in all patients and evaluated according to the Oxford Classification (1 – present, 0 – absent: M – mesangial hypercellularity; E– endocapillary hypercellularity; S – segmental sclerosis/adhesion; T – tubular atrophy/interstitial fibrosis), and was calculated as the total score (sum of M, E, S, T). At the end of follow-up, the serum GDIgA1 concentration was measured.

Results
The serum GDIgA1 concentration in patients with IgAN and HSN was significantly higher than in the control group. No significant differences in mean proteinuria, erythrocyturia, GFR, MEST score, or GDIgA1 in serum, as well as the duration of follow-up between IgAN and HSN were observed. Baseline serum IgA concentration and time to kidney biopsy were significantly higher in children with IgAN than in children with HSN. We observed a positive correlation between GDIgA1 and IgA levels (r = 0.53), and GDIgA1 and serum creatinine levels (r = 0.5), as well as negative correlation between GDIgA1 and GFR (r = –0.37).

Conclusions
Serum GDIgA1 level may have a prognostic value in children with IgAN and HSN; however, to fully elucidate its clinical potential further studies performed in larger patient cohorts are required.

keywords:

Serum GDIgA1 levels in children with IgA nephropathy and Henoch-Schönlein nephritis

galactose deficient IgA1, IgAN, HSN, children