Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report

Magdalena Żychowska; Aleksandra Batycka-Baran; Wojciech Baran; Joanna Maj

doi:10.5114/dr.2016.62888

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2016
vol. 103

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Original paper

Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report

Magdalena Żychowska

,

Aleksandra Batycka-Baran

,

Wojciech Baran

,

Joanna Maj

Przegl Dermatol 2016, 103, 371–375

DOI: https://doi.org/10.5114/dr.2016.62888

Online publish date: 2016/10/20

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Introduction. Epidermal growth factor receptor inhibitors (EGFRI) are commonly used in the treatment of solid tumors. Cutaneous side effects occur in 80% of patients and are the most frequent adverse events. However, cicatricial alopecia is a rarely described side effect of EGFRI.

Objective. To present cutaneous toxicities in a patient treated with erlotinib and underscore cicatricial alopecia, rarely described in the literature.

Case report. We present a 63-year-old woman diagnosed with non-small cell lung cancer and treated with erlotinib, who developed extensive papulo-pustular eruption with severe involvement of the scalp and cicatricial alopecia. Other adverse events included trichomegaly, paronychia, granuloma pyogenicum-like lesions, dryness of the skin and pruritus.

Conclusions. Cicatricial alopecia in the presented patient may be a result of delayed introduction of dermatological treatment. Therefore, all dermatologists should be aware of treatment modalities of EGFRI-induced toxicities.

keywords:

Severe cicatricial alopecia as a rare cutaneous side effect due to erlotinib – case report

Magdalena Żychowska , Aleksandra Batycka-Baran , Wojciech Baran , Joanna Maj

erlotinib, alopecia, cicatricial alopecia, epidermal growth factor receptor inhibitors

Magdalena Żychowska

,

Aleksandra Batycka-Baran

,

Wojciech Baran

,

Joanna Maj