Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state

Magdalena Sokołowska-Gadoux; Agnieszka Pietrusik; Agata Chobot; Przemysława Jarosz-Chobot

doi:10.5114/pedm.2022.114668

eISSN: 2083-8441
ISSN: 2081-237X

Pediatric Endocrinology Diabetes and Metabolism

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

Journal integrated with

2/2022
vol. 28

Send email

Copy url:

abstract:

Case report

Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state

Magdalena Sokołowska-Gadoux

¹

,

Agnieszka Pietrusik

²

,

Agata Chobot

³

,

Przemysława Jarosz-Chobot

^{4, 5}

Department of Children’s Diabetology and Pediatrics, John Paul II Upper Silesian Child Health Centre, Poland
Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Poland
Department of Pediatrics, Institute of Medical Sciences, University of Opole, Poland and Department of Pediatrics, University Clinical Hopsital, Opole, Poland
Department of Children’s Diabetology and Pediatrics, Medical University of Silesia, Poland
Regional Consultant for Pediatric Endocrinology and Diabetes, Poland

Pediatr Endocrinol Diabetes Metab 2022; 28 (2): 162–167

DOI: https://doi.org/10.5114/pedm.2022.114668

Online publish date: 2022/03/25

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Sokołowska-Gadoux M, Pietrusik A, Chobot A, Jarosz-Chobot P. Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state. Pediatric Endocrinology Diabetes and Metabolism. 2022;28(2):162-167. doi:10.5114/pedm.2022.114668.

APA

Sokołowska-Gadoux, M., Pietrusik, A., Chobot, A.,  & Jarosz-Chobot, P. (2022). Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state. Pediatric Endocrinology Diabetes and Metabolism, 28(2), 162-167. https://doi.org/10.5114/pedm.2022.114668

Chicago

Sokołowska-Gadoux, Magdalena, Agnieszka Pietrusik, Agata Chobot,  and Przemysława Jarosz-Chobot. 2022. "Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state". Pediatric Endocrinology Diabetes and Metabolism 28 (2): 162-167. doi:10.5114/pedm.2022.114668.

Harvard

Sokołowska-Gadoux, M., Pietrusik, A., Chobot, A.,  and Jarosz-Chobot, P. (2022). Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state. Pediatric Endocrinology Diabetes and Metabolism, 28(2), pp.162-167. https://doi.org/10.5114/pedm.2022.114668

MLA

Sokołowska-Gadoux, Magdalena et al. "Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state." Pediatric Endocrinology Diabetes and Metabolism, vol. 28, no. 2, 2022, pp. 162-167. doi:10.5114/pedm.2022.114668.

Vancouver

Sokołowska-Gadoux M, Pietrusik A, Chobot A, Jarosz-Chobot P. Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state. Pediatric Endocrinology Diabetes and Metabolism. 2022;28(2):162-167. doi:10.5114/pedm.2022.114668.

PlumX metrics:

The hyperosmolar hyperglycaemic state (HHS) is a very severe condition characterised by hyperosmolality, hyperglycaemia and dehydration without significant ketosis. The article presents the case of a 14.5-year-old cachectic patient with diagnosed HHS. Appropriate treatment per the ISPAD Guidelines was implemented. After metabolic stabilisation was achieved, the patient was transferred for further treatment to the Pediatric Gastroenterology Department due to her life-threatening cachexia. Normal glucose levels were observed during hospitalisation and the patient required no further insulin supplementation. Unfortunately, two months after discharge from hospital, the patient suffered sudden death at home. The patient did not live until full diabetological diagnostics could be performed. The transient hyperglycaemia may have been caused by a very early stage of type 1 diabetes (pre-diabetes), malnutrition-related diabetes mellitus (MRDM) or stress-induced hyperglycaemia (SIH). The case demonstrates that HHS can develop not only secondary to diabetes, but also be a severe complication of transient carbohydrate metabolism disorders in the course of cachexia.

keywords:

Severe malnutrition as a cause of transient carbohydrate metabolism disorders which evolved into hyperosmolar hyperglycaemic state

Magdalena Sokołowska-Gadoux 1 , Agnieszka Pietrusik 2 , Agata Chobot 3 , Przemysława Jarosz-Chobot 4, 5

carbohydrate metabolism disorders, cachexia, malnutrition related diabetes mellitus, hyperosmolar hyperglycaemic state

Magdalena Sokołowska-Gadoux

¹

,

Agnieszka Pietrusik

²

,

Agata Chobot

³

,

Przemysława Jarosz-Chobot

^{4, 5}