Shear-wave elastography for evaluation of hepatic stiffness in chronic viral hepatitis B and C

Diana Martonik; Alicja Wandałowicz; Łukasz Supronowicz; Anatol Panasiuk; Anna Parfieniuk-Kowerda; Robert Flisiak

doi:10.5114/ceh.2023.129112

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Shear-wave elastography for evaluation of hepatic stiffness in chronic viral hepatitis B and C

Diana Martonik

¹

,

Alicja Wandałowicz

²

,

Łukasz Supronowicz

^{1, 2}

,

Anatol Panasiuk

^{1, 3}

,

Anna Parfieniuk-Kowerda

^{1, 2}

,

Robert Flisiak

^{1, 2}

Medical University of Bialystok, Bialystok, Poland
Medical University of Bialystok Clinical Hospital, Bialystok, Poland
Voivodeship Hospital in Białystok, Poland

Clin Exp HEPATOL 2023; 9, 2: 179-186

DOI: https://doi.org/10.5114/ceh.2023.129112

Online publish date: 2023/06/30

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Aim of the study:
To analyse the consistency between 2D shear-wave elastography (2D-SWE) stiffness and fibrosis in liver biopsy in patients with chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. The secondary aim of the study was to analyse the consistency between liver stiffness in 2D-SWE and transient elastography (TE) measurements in patients with chronic hepatitis B and C.

Material and methods:
The study compared the results of hepatic stiffness assessment with 2D-SWE to available past liver biopsy reports in 153 patients with chronic HBV (n = 51) and HCV (n = 102) infection. In 43 patients with both hepatitides HBV (n = 8) and HCV (n = 35) we performed FibroScan on the same day as 2D-SWE. The appropriate statistical tests were applied for the analysis.

Results:
Stiffness values analysed in the whole studied population showed a significant positive correlation with a stage of liver fibrosis in biopsy (r = 0.555, p < 0.001). If 2D-SWE was carried out within 24 months since liver biopsy the consistency of the results was 96%, and if the period between procedures exceeded 24 months the consistency was 81%. In 43 patients with both 2D-SWE and TE the coherence (r = 0.872, p < 0.001) and consistency (95%) between these two methods were high.

Conclusions:
Liver stiffness measured with 2D-SWE showed good consistency with stage of liver fibrosis in liver biopsies, particularly in HCV infected patients, and if the period between procedures did not exceed 24 months.

keywords:

Shear-wave elastography for evaluation of hepatic stiffness in chronic viral hepatitis B and C

Diana Martonik 1 , Alicja Wandałowicz 2 , Łukasz Supronowicz 1, 2 , Anatol Panasiuk 1, 3 , Anna Parfieniuk-Kowerda 1, 2 , Robert Flisiak 1, 2

chronic hepatitis C, liver fibrosis, shear wave elastography, liver stiffness, chronic hepatitis B

Diana Martonik

¹

,

Alicja Wandałowicz

²

,

Łukasz Supronowicz

^{1, 2}

,

Anatol Panasiuk

^{1, 3}

,

Anna Parfieniuk-Kowerda

^{1, 2}

,

Robert Flisiak

^{1, 2}