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Original paper

Suppression of the lncRNA TUG1 alleviates neuropathic pain in rats with chronic contractile injury via the miR-29b-3p/HMGB1 axis

Jingjing Dong
1
,
Yonghong Ding
2
,
Xia Geng
3
,
Linkai Jiang
3
,
Aiping Ouyang
4

  1. Department of Anesthesiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, 046000, China
  2. Department of Anesthesiology, Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, China
  3. Department of Pain, Dongying People’s Hospital, Dongying, Shandong, 257091, China
  4. Department of Anesthesiology, Ganzhou People’s Hospital, Ganzhou, Jiangxi, 341000, China
Folia Neuropathol 2024; 62
DOI: https://doi.org/10.5114/fn.2024.141512
Online publish date: 2024/08/05
Article file
- Suppression.pdf  [3.07 MB]
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1. Alomar SY, Gheit R, Enan ET, El-Bayoumi KS, Shoaeir MZ, Elkazaz AY, Al Thagfan SS, Zaitone SA, El-Sayed RM. Novel mechanism for memantine in attenuating diabetic neuropathic pain in mice via downregulating the spinal HMGB1/TRL4/NF-kB inflammatory axis. Pharmaceuticals (Basel) 2021; 14: 307.
2. Brandenburger T, Johannsen L, Prassek V, Kuebart A, Raile J, Wohlfromm S, Köhrer K, Huhn R, Hollmann MW, Hermanns H. MiR-34a is differentially expressed in dorsal root ganglia in a rat model of chronic neuropathic pain. Neurosci Lett 2019; 708: 134365.
3. Cao S, Yuan J, Zhang D, Wen S, Wang J, Li Y, Deng W. Transcriptome changes in dorsal spinal cord of rats with neuropathic pain. J Pain Res 2019; 12: 3013-3023.
4. Cheng J, Duan Y, Zhang F, Shi J, Li H, Wang F, Li H. The role of lncRNA TUG1 in the Parkinson disease and its effect on microglial inflammatory response. Neuromolecular Med 2021; 23: 327-334.
5. Dalgaard LT, Sorensen AE, Hardikar AA, Joglekar MV. The microRNA-29 family: role in metabolism and metabolic disease. Am J Physiol Cell Physiol 2022; 323: C367-C377.
6. Du Y, Xu CL, Yu J, Liu K, Lin SD, Hu TT, Qu FH, Guo F, Lou GD, Nishibori M, Hu WW, Chen Z, Zhang SH. HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain. J Headache Pain 2022; 23: 102.
7. Fan F, Lei M. Mechanisms underlying curcumin-induced neuroprotection in cerebral ischemia. Front Pharmacol 2022; 13: 893118.
8. Gong W, Li J, Zhu G, Wang Y, Zheng G, Kan Q. Chlorogenic acid relieved oxidative stress injury in retinal ganglion cells through IncRNA-TUG1/Nrf2. Cell Cycle 2019; 18: 1549-1559.
9. Guo Y, Sun Z, Chen M, Lun J. LncRNA TUG1 regulates proliferation of cardiac fibroblast via the miR-29b-3p/TGF-beta1 axis. Front Cardiovasc Med 2021; 8: 646806.
10. Han J, Zhang Z, Zhang Z, Yang S. Artemisinin relieves myocardial ischemia-reperfusion injury via modulating miR-29b-3p and hemicentin 1. Front Pharmacol 2022; 13: 918966.
11. He Y, Li M, Wujisiguleng, Lv B, Huan Y, Liu B, Wang D, Yu H, Zhang L, Shi Z. Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1/miR-214/HSP27 axis. Biosci Rep 2018; 38: BSR20180895.
12. Hisaoka-Nakashima K, Ohata K, Yoshimoto N, Tokuda S, Yoshii N, Nakamura Y, Wang D, Liu K, Wake H, Yoshida T, Ago Y, Hashimoto K, Nishibori M, Morioka N. High-mobility group box 1- mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain. Exp Neurol 2022; 355: 114146.
13. Hou K, Li G, Zhao J, Xu B, Zhang Y, Yu J, Xu K. Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic- ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway. J Neuroinflammation 2020; 17: 46.
14. Hu JZ, Rong ZJ, Li M, Li P, Jiang LY, Luo ZX, Duan CY, Cao Y, Lu HB. Silencing of lncRNA PKIA-AS1 attenuates spinal nerve ligation- induced neuropathic pain through epigenetic downregulation of CDK6 expression. Front Cell Neurosci 2019; 13: 50.
15. Lai L, Wang Y, Peng S, Guo W, Wei G, Li L, Xia Z, Li F, Xu S. Bupivacaine induces ROS-dependent autophagic damage in DRG neurons via TUG1/mTOR in a high-glucose environment. Neurotox Res 2022; 40: 111-126.
16. Lei X, Fang X, Chen T, Pu C, Yang J, Liu H. LncRNA TUG1 promoted stabilization of BAG5 by binding DDX3X to exacerbate ketamine- induced neurotoxicity. Neurotox Res 2022; 40: 1989-2000.
17. Li DL, Zheng BB, Zeng X, Li J, Dai RZ. Silencing of long noncoding RNA TUG1 ameliorates atherosclerosis-induced myocardial injury by upregulating microRNA-30b-3p and downregulating Brd4. J Cardiovasc Pharmacol 2023; 81: 45-54.
18. Li F, Yu JH, Jiang HX, Zhang HK, Cai Q, Liu ZM, Li MC, Chen QX. Taurine-upregulated gene 1 attenuates cerebral angiogenesis following ischemic stroke in rats. Biomed Res Int 2022; 2022: 1037525.
19. Li H, Wan HQ, Zhao HJ, Luan SX, Zhang CG. Identification of candidate genes and miRNAs associated with neuropathic pain induced by spared nerve injury. Int J Mol Med 2019; 44: 1205-1218.
20. Li X, Wang SW, Li XL, Yu FY, Cong HM. Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression. Inflamm Res 2020; 69: 897-910.
21. Li Z, Li A, Yan L, Yang T, Xu W, Fan P. Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis. Mol Med 2020; 26: 104.
22. Liu D, Wang J, Liu M. Long noncoding RNA TUG1 promotes proliferation and inhibits apoptosis in multiple myeloma by inhibiting miR-29b-3p. Biosci Rep 2019; 39: BSR20182489.
23. Lu Z, Zhang Y, Li Y. LncRNA FTX ameliorates neuropathic pain by targeting miR-320a in a rat model of chronic constriction injury. Folia Neuropathol 2023; 61: 291-300.
24. Naseer S, Abelleira-Hervas L, Savani D, de Burgh R, Aleksynas R, Donat CK, Syed N, Sastre M. Traumatic brain injury leads to alterations in contusional cortical miRNAs involved in dementia. Biomolecules 2022; 12: 1457.
25. Oh YM, Lee SW, Kim WK, Chen S, Church VA, Cates K, Li T, Zhang B, Dolle RE, Dahiya S, Pak SC, Silverman GA, Perlmutter DH, Yoo AS. Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy. Nat Neurosci 2022; 25: 1420-1433.
26. Pan Z, Du S, Wang K, Guo X, Mao Q, Feng X, Huang L, Wu S, Hou B, Chang YJ, Liu T, Chen T, Li H, Bachmann T, Bekker A, Hu H, Tao YX. Downregulation of a dorsal root ganglion-specifically enriched long noncoding RNA is required for neuropathic pain by negatively regulating RALY-triggered Ehmt2 expression. Adv Sci (Weinh) 2021; 8: e2004515.
27. Pang H, Ren Y, Li H, Chen C, Zheng X. LncRNAs linc00311 and AK141205 are identified as new regulators in STAT3-mediated neuropathic pain in bCCI rats. Eur J Pharmacol 2020; 868: 172880.
28. Provenzano F, Nyberg S, Giunti D, Torazza C, Parodi B, Bonifacino T, Usai C, Kerlero de Rosbo N, Milanese M, Uccelli A, Shaw PJ, Ferraiuolo L, Bonanno G. Micro-RNAs shuttled by extracellular vesicles secreted from mesenchymal stem cells dampen astrocyte pathological activation and support neuroprotection in in-vitro models of ALS. Cells 2022; 11: 3923.
29. Qu P, Cheng K, Gao Q, Li Y, Wang M. Application value of serum Hcy, TLR4, and CRP in the diagnosis of cerebral small vessel disease. Evid Based Complement Alternat Med 2022; 2022: 4025965.
30. Ruan J, Cui X, Yan H, Jia C, Ou T, Shang Z. Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury. PeerJ 2023; 11: e16042.
31. Silambarasan M, Tan JR, Karolina DS, Armugam A, Kaur C, Jeyaseelan K. MicroRNAs in hyperglycemia induced endothelial cell dysfunction. Int J Mol Sci 2016; 17: 518.
32. Stoffel EC, Ulibarri CM, Folk JE, Rice KC, Craft RM. Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats. J Pain 2005; 6: 261-274.
33. Su M, Yu T, Yu Y, Cheng Q, Zheng Y, Liao R, Zeng Z. hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus. Exp Biol Med (Maywood) 2022; 247: 1609-1618.
34. Tan Y, Sun D, Chen J, Li R, Wang S. Ginsenoside Rb3 alleviates smoke-induced lung injury via the H19/miR-29b-3p/HGMB1/ TLR4 signalling pathway. J Cell Mol Med 2021; 25: 2725-2729.
35. Tian M, Yang J, Yan X, Cao Y, Liu Y, Lei Y, Lv H. Knockdown of lncRNA TUG1 alleviates diabetic retinal vascular dysfunction through regulating miR-524-5p/FGFR2. Bioengineered 2022; 13: 12661-12672.
36. Wang S, Yi P, Wang N, Song M, Li W, Zheng Y. LncRNA TUG1/ miR-29c-3p/SIRT1 axis regulates endoplasmic reticulum stressmediated renal epithelial cells injury in diabetic nephropathy model in vitro. PLoS One 2021; 16: e0252761.
37. Wang X, Liu Q. Dexmedetomidine relieved neuropathic pain and inflammation response induced by CCI through HMGB1/ TLR4/NF-kappaB signal pathway. Biol Pharm Bull 2021; doi: 10.1248/bpb.b21-00329.
38. Wang XY, Ma HJ, Xue M, Sun YL, Ren A, Li MQ, Huang ZH, Huang C. Anti-nociceptive effects of Sedum Lineare Thunb. on spared nerve injury-induced neuropathic pain by inhibiting TLR4/ NF-kappaB signaling in the spinal cord in rats. Biomed Pharmacother 2021; 135: 111215.
39. Wang Y, Ye F, Huang C, Xue F, Li Y, Gao S, Qiu Z, Li S, Chen Q, Zhou H, Song Y, Huang W, Tan W, Wang Z. Bioinformatic analysis of potential biomarkers for spinal cord-injured patients with intractable neuropathic pain. Clin J Pain 2018; 34: 825-830.
40. Wu H, Li Y, Wang X, Zhang Z, Huang Y. Long non-coding RNA TUG1 knockdown prevents neurons from death to alleviate acute spinal cord injury via the microRNA-338/BIK axis. Bioengineered 2021; 12: 5566-5582.
41. Wu J, Fan CL, Ma LJ, Liu T, Wang C, Song JX, Lv QS, Pan H, Zhang CN, Wang JJ. Distinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients. Thromb Haemost 2017; 117: 992-1001.
42. Wu J, Wang C, Ding H. LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models. Mol Med Rep 2020; 21: 291-303.
43. Wu Z, Li M. High-mobility group box 1 in spinal cord injury and its potential role in brain functional remodeling after spinal cord injury. Cell Mol Neurobiol 2023; 43: 1005-1017.
44. Xiang P, Hu J, Wang H, Luo Y, Gu C, Tan X, Tu Y, Guo W, Chen L, Gao L, Chen R, Yang J. miR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2. Cell Death Discov 2022; 8: 89.
45. Xiao X, Li W, Rong D, Xu Z, Zhang Z, Ye H, Xie L, Wu Y, Zhang Y, Wang X. Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis. Cell Death Discov 2021; 7: 212.
46. Xiao X, Li W, Xu Z, Sun Z, Ye H, Wu Y, Zhang Y, Xie L, Jiang D, Jia R, Wang X. Extracellular vesicles from human umbilical cord mesenchymal stem cells reduce lipopolysaccharide-induced spinal cord injury neuronal apoptosis by mediating miR-29b-3p/PTEN. Connect Tissue Res 2022; 63: 634-649.
47. Xu C, Liu T, Zhang Y, Feng Y. Effect of surgical damage to spinal nerve on dorsal-root ganglion gene expressions: Comprehensive analysis of differentially expressed genes. Asian J Surg 2022; 45: 2618-2625.
48. Xue LX, Chen SF, Xue SX, Liu PD, Liu HB. LncRNA TUG1 compromised neuronal mitophagy in cerebral ischemia/reperfusion injury by targeting sirtuin 1. Cell Biol Toxicol 2022; 38: 1121-1136.
49. Yang B, Liang RS, Wu XY, Lin YJ. LncRNA TUG1 inhibits neuronal apoptosis in status epilepticus rats via targeting the miR-421/ mTOR axis. Cell Signal 2020; 76: 109787.
50. Yang X, Xin N, Qu HJ, Wei L, Han Z. Long noncoding RNA TUG1 facilitates cell ovarian cancer progression through targeting MiR-29b-3p/MDM2 axis. Anat Rec (Hoboken) 2020; 303: 3024- 3034.
51. Yao M, Luo Y, Li H, Liao S, Yu J. LncRNA Tug1 contributes poststroke NLRP3 inflammasome-dependent pyroptosis via miR-145a-5p/Tlr4 axis. Mol Neurobiol 2022; 59: 6701-6712.
52. Yu M, Huang J, Zhu T, Lu J, Liu J, Li X, Yan X, Liu F. Liraglutide-loaded PLGA/gelatin electrospun nanofibrous mats promote angiogenesis to accelerate diabetic wound healing via the modulation of miR-29b-3p. Biomater Sci 2020; 8: 4225-4238.
53. Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, Tang F, Li Z, Zhou J, Gao D, Tian X, Yao J. Carnosic acid alleviates BDL-induced liver fibrosis through miR-29b-3p-mediated inhibition of the highmobility group box 1/Toll-like receptor 4 signaling pathway in rats. Front Pharmacol 2017; 8: 976.
54. Zhang W, Zhou L, Zhang C. LncRNA Miat promotes neuropathic pain through miR-362-3p/BAMBI signaling axis. Exp Cell Res 2022; 420: 113359.
55. Zhang Y, Chen Q, Nai Y, Cao C. Suppression of miR-155 attenuates neuropathic pain by inducing an M1 to M2 switch in microglia. Folia Neuropathol 2020; 58: 70-82.
56. Zhang YU, Ye G, Zhao J, Chen Y, Kong L, Sheng C, Yuan L. Exosomes carried miR-181c-5p alleviates neuropathic pain in CCI rat models. An Acad Bras Cienc 2022; 94: e20210564.
57. Zhao C, Li Y, Hu X, Wang R, He W, Wang L, Qi L, Tong S. LncRNA HCP5 promotes cell invasion and migration by sponging miR- 29b-3p in human bladder cancer. Onco Targets Ther 2020; 13: 11827-11838.
58. Zhao H, Wang Y, Liang C, Xie M. LncRNA FOXD3-AS1/miR-128-3p axis-mediated IGF2BP3 in glioma stimulates cancer angiogenesis and progression. Folia Neuropathol 2023; 61: 168-184.
59. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-110.
60. Zong L, Huang P, Song Q, Kang Y. Bone marrow mesenchymal stem cells-secreted exosomal H19 modulates lipopolysaccharides- stimulated microglial M1/M2 polarization and alleviates inflammation-mediated neurotoxicity. Am J Transl Res 2021; 13: 935-951.
Copyright: © 2024 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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