eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2020
vol. 15
 
Share:
Send email
Share:
abstract:
Original paper

Survivin expression starts before hepatocellular cancer development in the liver of chronic hepatitis B patients: a pilot, cross-sectional study

Muhammet Yener Akpinar
1
,
Gulcin Guler Simsek
2
,
Evrim Kahramanoglu Aksoy
1
,
Ferda Pirincci Sapmaz
1
,
Selen Kantarci
3
,
Metin Uzman
1
,
Yasar Nazligul
1

  1. Gastroenterology Department, Kecioren Training and Research Hospital, Ankara, Turkey
  2. Pathology Department Kecioren Training and Research Hospital, Ankara, Turkey
  3. Internal Medicine Department, Kecioren Training and Research Hospital, Ankara, Turkey
Gastroenterology Rev 2020; 15 (2): 138–143
DOI: https://doi.org/10.5114/pg.2019.87081
Online publish date: 2019/08/08
View full text Get citation
 
PlumX metrics:
Introduction
Survivin expression is well known feature of hepatocellular carcinoma (HCC); however, there is no information about survivin expression in chronic hepatitis B (CHB).

Aim
Investigating survivin expression in the liver of CHB patients.

Material and methods
This is a single-centre, cross-sectional study. Seventy-five CHB patients and eight control patients were enrolled into the study between 2008 and 2018. Immunohistochemical study was performed by using anti-survivin antibody to evaluate survivin immunoreactivity.

Results
Survivin immunoreactivity was significantly higher in CHB patients compared to controls (p = 0.008). Also, the degree of survivin immunoreactivity was significantly higher in CHB patients (p = 0.027). Between the anti-survivin-positive and anti-survivin-negative groups, baseline laboratory parameters and initial pathology features were not significantly different.

Conclusions
This is the first study evaluating survivin expression in CHB patients. Understanding the possible relationship between survivin expression and HCC development in this population can promote new studies in terms of new therapies and treatment timing.

keywords:

apoptosis, chronic hepatitis B, surviving
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.