The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases

Uğur Altaş; Sevinç Taşar; Nurbanu Başdoğan; Halil Alkaya; Seda Çevik; Zeynep M. Altaş; Mehmet Yaşar Özkars

doi:10.5114/ada.2025.147855

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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1/2025
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abstract:

Original paper

The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases

Uğur Altaş

¹

,

Sevinç Taşar

²

,

Nurbanu Başdoğan

²

,

Halil Alkaya

¹

,

Seda Çevik

¹

,

Zeynep M. Altaş

^{3, 4}

,

Mehmet Yaşar Özkars

¹

Department of Pediatric Allergy and Immunology, Umraniye Training and Research Hospital, Istanbul, Türkiye
Department of Paediatric Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Umraniye, Istanbul, Türkiye
Maltepe District Health Directorate, Istanbul, Türkiye
Department of Public Health, International School of Medicine, Istanbul Medipol University, Istanbul, Türkiye

Adv Dermatol Allergol 2025; XLII (1): 105-109

DOI: https://doi.org/10.5114/ada.2025.147855

Online publish date: 2025/02/20

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AMA

Altaş U, Taşar S, Başdoğan N, et al. The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2025;42(1):105-109. doi:10.5114/ada.2025.147855.

APA

Altaş, U., Taşar, S., Başdoğan, N., Alkaya, H., Çevik, S.,  & Altaş, Z. et al. (2025). The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 42(1), 105-109. https://doi.org/10.5114/ada.2025.147855

Chicago

Altaş, Uğur, Sevinç Taşar, Nurbanu Başdoğan, Halil Alkaya, Seda Çevik, Zeynep M. Altaş,  and Mehmet Yaşar Özkars. 2025. "The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 42 (1): 105-109. doi:10.5114/ada.2025.147855.

Harvard

Altaş, U., Taşar, S., Başdoğan, N., Alkaya, H., Çevik, S., Altaş, Z.,  and Özkars, M. (2025). The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 42(1), pp.105-109. https://doi.org/10.5114/ada.2025.147855

MLA

Altaş, Uğur et al. "The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 42, no. 1, 2025, pp. 105-109. doi:10.5114/ada.2025.147855.

Vancouver

Altaş U, Taşar S, Başdoğan N, Alkaya H, Çevik S, Altaş Z et al. The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2025;42(1):105-109. doi:10.5114/ada.2025.147855.

Introduction:
An impaired skin barrier has been reported in allergic diseases.

Aim:
In this study, we aimed to evaluate dermis thickness in children with house dust allergy without skin symptoms.

Material and methods:
This cross-sectional study included children aged 4–18 years with asthma and/or allergic rhinitis. Participants were divided into three groups: healthy controls (n = 50), patients sensitized to house dust mites (n = 60), and patients with negative house dust mite tests (n = 48). The thickness of the dermis layers of the skin was measured at the cubital fossa using an ultrasound.

Results:
The median age and gender distribution were similar across the house dust mite-positive and -negative groups and the healthy control group. There was no significant difference between the groups in terms of dermis thickness (p = 0.053). Absolute eosinophils and eosinophil percentage were significantly negatively correlated with dermis (p < 0.05). There was no significant correlation between total IgE, house dust mite specific IgE and skin test values and skin thickness (p > 0.05).

Conclusions:
The findings of this study highlight the impact of house dust mite sensitization on skin thickness, offering potential contributions to the management and treatment strategies of allergic diseases.

keywords:

The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases

Uğur Altaş 1 , Sevinç Taşar 2 , Nurbanu Başdoğan 2 , Halil Alkaya 1 , Seda Çevik 1 , Zeynep M. Altaş 3, 4 , Mehmet Yaşar Özkars 1

house dust mite sensitization, skin barrier, skin thickness, children, allergy

Uğur Altaş

¹

,

Sevinç Taşar

²

,

Nurbanu Başdoğan

²

,

Halil Alkaya

¹

,

Seda Çevik

¹

,

Zeynep M. Altaş

^{3, 4}

,

Mehmet Yaşar Özkars

¹