The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model

Meili Yang; Yafang Chen; Zhengang Wu; Yaping Zhang; Ruowei Cai; Lichao Ye; Yinhui Huang; Lingxing Wang; Huiling He

doi:10.5114/fn.2018.78693

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2018
vol. 56

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abstract:

Original paper

The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model

Meili Yang

,

Yafang Chen

,

Zhengang Wu

,

Yaping Zhang

,

Ruowei Cai

,

Lichao Ye

,

Yinhui Huang

,

Lingxing Wang

,

Huiling He

Folia Neuropathol 2018; 56 (3): 159-166

DOI: https://doi.org/10.5114/fn.2018.78693

Online publish date: 2018/09/28

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AMA

Yang M, Chen Y, Wu Z, et al. The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model. Folia Neuropathologica. 2018;56(3):159-166. doi:10.5114/fn.2018.78693.

APA

Yang, M., Chen, Y., Wu, Z., Zhang, Y., Cai, R.,  & Ye, L. et al. (2018). The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model. Folia Neuropathologica, 56(3), 159-166. https://doi.org/10.5114/fn.2018.78693

Chicago

Yang, Meili, Yafang Chen, Zhengang Wu, Yaping Zhang, Ruowei Cai, Lichao Ye,  and Yinhui Huang et al. 2018. "The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model". Folia Neuropathologica 56 (3): 159-166. doi:10.5114/fn.2018.78693.

Harvard

Yang, M., Chen, Y., Wu, Z., Zhang, Y., Cai, R., Ye, L., Huang, Y., Wang, L.,  and He, H. (2018). The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model. Folia Neuropathologica, 56(3), pp.159-166. https://doi.org/10.5114/fn.2018.78693

MLA

Yang, Meili et al. "The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model." Folia Neuropathologica, vol. 56, no. 3, 2018, pp. 159-166. doi:10.5114/fn.2018.78693.

Vancouver

Yang M, Chen Y, Wu Z, Zhang Y, Cai R, Ye L et al. The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model. Folia Neuropathologica. 2018;56(3):159-166. doi:10.5114/fn.2018.78693.

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The aim of this study was to investigate the effect and mechanism of chronic intermittent hypoxia (CIH) on cerebral injury using the ischemia-reperfusion rat model. In total, 36 SD rats were divided into three groups: pseudo-surgery group (sham group), ischemia-reperfusion (IR) group (CIR group), and CIH intervention group (CIH group). The IR model was established using the suture-occluded method. CIH intervention was performed starting at 12 weeks prior to the establishment of the IR model for rats in the CIH group. Ultra-microstructure was examined using an electron microscope. Expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) in rat brain tissue was evaluated by immunohistochemical methods and western blot assays. The neurological deficit scores of rats in the CIH group were higher than those in the CIR group (p < 0.05). Using electron microscopy, we observed more severe edema around the capillaries of the rat brain that resulted in more pressure on the vascular wall of the capillaries in the CIH group compared to the CIR group. The expression of ICAM-1 and VEGF in rat brain tissue was rare in the sham group, but was significantly elevated in the CIR group (p < 0.05) and even higher in the CIH group, compared to the CIR group. Hence, the brain injury in ischemia-reperfusion rat models following CIH intervention may be related to the increased expression of ICAM-1 and VEGF.

keywords:

The impact of chronic intermittent hypoxia on the expression of intercellular cell adhesion molecule-1 and vascular endothelial growth factor in the ischemia-reperfusion rat model

Meili Yang , Yafang Chen , Zhengang Wu , Yaping Zhang , Ruowei Cai , Lichao Ye , Yinhui Huang , Lingxing Wang , Huiling He

chronic intermittent hypoxia, ischemic reperfusion injury, ICAM-1, VEGF

Meili Yang

,

Yafang Chen

,

Zhengang Wu

,

Yaping Zhang

,

Ruowei Cai

,

Lichao Ye

,

Yinhui Huang

,

Lingxing Wang

,

Huiling He