The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma

Andrzej Namysłowski; Agnieszka Lipiec; Wojciech Zieliński; Filip Raciborski; Edyta Krzych-Fałta; Krzysztof Samoliński; Anna Szylling; Bolesław Samoliński

doi:10.5114/ada.2023.130287

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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5/2023
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abstract:

Original paper

The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma

Andrzej Namysłowski

¹

,

Agnieszka Lipiec

¹

,

Wojciech Zieliński

^{1, 2}

,

Filip Raciborski

¹

,

Edyta Krzych-Fałta

¹

,

Krzysztof Samoliński

³

,

Anna Szylling

⁴

,

Bolesław Samoliński

¹

Department of the Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
Department of Econometrics and Statistics, Warsaw University of Life Sciences, Warsaw, Poland
Department of Emergency Medical Services, Medical University of Warsaw, Warsaw, Poland
Department of Allergology and Clinical Immunology of the Central Clinical Hospital, Warsaw, Poland

Adv Dermatol Allergol 2023; XL (5): 611-616

DOI: https://doi.org/10.5114/ada.2023.130287

Online publish date: 2023/08/02

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AMA

Namysłowski A, Lipiec A, Zieliński W, et al. The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(5):611-616. doi:10.5114/ada.2023.130287.

APA

Namysłowski, A., Lipiec, A., Zieliński, W., Raciborski, F., Krzych-Fałta, E.,  & Samoliński, K. et al. (2023). The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(5), 611-616. https://doi.org/10.5114/ada.2023.130287

Chicago

Namysłowski, Andrzej, Agnieszka Lipiec, Wojciech Zieliński, Filip Raciborski, Edyta Krzych-Fałta, Krzysztof Samoliński,  and Anna Szylling et al. 2023. "The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 40 (5): 611-616. doi:10.5114/ada.2023.130287.

Harvard

Namysłowski, A., Lipiec, A., Zieliński, W., Raciborski, F., Krzych-Fałta, E., Samoliński, K., Szylling, A.,  and Samoliński, B. (2023). The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(5), pp.611-616. https://doi.org/10.5114/ada.2023.130287

MLA

Namysłowski, Andrzej et al. "The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 40, no. 5, 2023, pp. 611-616. doi:10.5114/ada.2023.130287.

Vancouver

Namysłowski A, Lipiec A, Zieliński W, Raciborski F, Krzych-Fałta E, Samoliński K et al. The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(5):611-616. doi:10.5114/ada.2023.130287.

Introduction:
Specific immunoglobulins E (sIgE) are important parameters for the estimation of severity of allergic diseases.

Aim:
To determine the relationship between the concentration of specific IgE antibodies in serum and types of asthma.

Material and methods:
The concentration of sIgE antibodies against allergens Dermatophagoides pteronyssinus, cat dander, timothy grass, and Alternaria alternata were determined in the serum of 4077 respondents randomly selected from 8 regions (ECAP study). The positive results of sIgE (≥ 0.35 IU/ml or ≥ 0.7 IU/ml) were correlated to clinical diagnosis (types of asthma, skin-prick tests).

Results:
sIgE antibodies against any allergen were detected in 9.9% (classes 1–6)/7.6% (classes 2–6) of healthy respondents. Comparing sIgE antibodies of respondents with intermittent asthma to sIgE antibodies of respondents with persistent asthma, no statistically significant differences were identified. Relating to allergens of D. pteronyssinus, cat dander, and A. alternata, sIgE antibodies were more frequently detected in respondents with atopic asthma and a negative skin-prick test as compared to healthy respondents with a negative skin-prick test (p < 0.005 to p < 0.001). Relating to allergens of D. pteronyssinus, cat dander, and timothy grass, sIgE antibodies were more frequently detected in respondents with atopic asthma and a weakly positive skin-prick test as compared to healthy respondents with weakly positive skin-prick test (p < 0.05 to p < 0.001).

Conclusions:
Regarding subjects with a negative or weakly positive skin test, when sIgE antibodies to the same allergen are detected, asthma is much more likely to occur.

keywords:

The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part four. The relationship between the concentration of specific IgE antibodies in serum and types of asthma

Andrzej Namysłowski 1 , Agnieszka Lipiec 1 , Wojciech Zieliński 1, 2 , Filip Raciborski 1 , Edyta Krzych-Fałta 1 , Krzysztof Samoliński 3 , Anna Szylling 4 , Bolesław Samoliński 1

specific immunoglobulins E, skin prick test, asthma, ECAP

Andrzej Namysłowski

¹

,

Agnieszka Lipiec

¹

,

Wojciech Zieliński

^{1, 2}

,

Filip Raciborski

¹

,

Edyta Krzych-Fałta

¹

,

Krzysztof Samoliński

³

,

Anna Szylling

⁴

,

Bolesław Samoliński

¹