The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Agnieszka M. Śmigórska; Krzysztof Śmigórski

doi:10.5114/ppn.2017.69378

eISSN: 2720-5371
ISSN: 1230-2813

Advances in Psychiatry and Neurology/Postępy Psychiatrii i Neurologii

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2/2017
vol. 26

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abstract:

Review paper

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Agnieszka M. Śmigórska

,

Krzysztof Śmigórski

Adv Psychiatry Neurol 2017; 26 (2): 85-95

DOI: https://doi.org/10.5114/ppn.2017.69378

Online publish date: 2017/08/08

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Purpose: The aim of this article is to provide a summary of findings concerning olfactory loss associated with pathological neurodegenerative changes which occur over the course of Alzheimer’s disease.

Views: It is shown that compared with the healthy population, olfactory dysfunction is more pronounced in neurodegenerative diseases and precedes symptoms typical of those diseases. One of the primary differences between physiological, age-associated and pathological olfactory loss is the patients’ awareness of the deficit. Healthy hyposmic or even anosmic patients are often aware of the problems caused by this dysfunction; however, it is not the case for patients in the preclinical, prodromal or clinical stages of Alzheimer’s disease.

Conclusions: The clinical value of olfactory function assessments should be emphasized, as it may provide information about the potential prodromal symptoms of Alzheimer’s disease.

keywords:

The olfactory dysfunctions occurring in the course of Alzheimer’s disease

Agnieszka M. Śmigórska , Krzysztof Śmigórski

Alzheimer’s disease, olfaction disorders, olfactory perception, dementia, smell

Agnieszka M. Śmigórska

,

Krzysztof Śmigórski