eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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abstract:
Review paper

The role of fecal microbiota transplantation in selected neurodegenerative diseases and neurodevelopmental disorders

Anna Sopel
1
,
Wiktor Szczuciński
1
,
Tomasz Gosiewski
2
,
Dominika Salamon
3

  1. Students’ Scientific Group of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
  2. Microbiome Research Laboratory, Department of Molecular Medical Microbiology, Division of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
  3. Department of Molecular Medical Microbiology, Division of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
Gastroenterology Rev
DOI: https://doi.org/10.5114/pg.2024.146118
Online publish date: 2024/12/22
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Fecal microbiota transplantation (FMT) is a medical procedure that allows to establish a stable and healthy intestinal microbiota in various diseases believed to be related to a gut dysbiosis. Currently, FMT is successfully used to treat recurrent Clostridioides difficile infection. However, in recent years there has been evidence that changes in composition of gut microbiota may also be relevant in the pathogenesis of several neuropsychiatric and neurodevelopmental conditions including Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, autism spectrum disorders and schizophrenia. This review focuses on exploring the complex connection between gut microbiota and pathogenesis of these neurological conditions. It also presents current research on a possible use of FMT as a therapeutic intervention targeting the gut-brain axis.
keywords:

gut-brain axis, neuropsychiatric disorders, fecal microbiota transplantation, gastrointestinal microbiota, neurodevelopmental conditions
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