The significance of Agaricus blazei as an immunomodulator of the level of IL-17 in Balb/C mice with atherosclerosis

Dicky Tontowiputro; Djanggan Sargowo; Askandar Tjokroprawiro; Muhaimin Rifa’i

doi:10.5114/ceji.2020.94662

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

1/2020
vol. 45

Send email

Copy url:

abstract:

Experimental immunology

The significance of Agaricus blazei as an immunomodulator of the level of IL-17 in Balb/C mice with atherosclerosis

Dicky Kurniawan Tontowiputro

¹

,

Djanggan Sargowo

¹

,

Askandar Tjokroprawiro

¹

,

Muhaimin Rifa’i

²

Biomedical Department, Medical Faculty, University of Brawijaya, Malang, Indonesia
Biology Department, Faculty of Mathematics and Natural Sciences, University of Brawijaya, Malang, Indonesia

(Centr Eur J Immunol 2020; 45 (1): 1-8)

DOI: https://doi.org/10.5114/ceji.2020.94662

Online publish date: 2020/04/06

View full text Get citation

PlumX metrics:

Atherosclerosis is a disease caused by an inflammatory response which involved the interaction between endothelial cells, macrophages and lymphocytes, and is closely related to IL-17 regulation. This study is important to investigate the activity of Agaricus blazei in modulating the immunological activity based on the profile of CD4+IL-17+, CD8+IL-17+, and CD11b+ IL-17+ in high-fat diet (HFD)-induced Balb/c mice. Mice in dietary groups were fed with HFD and then fed with A. blazei extract with three different doses including D1 (100 mg/kg BW), D2 (200 mg/kg BW), and D3 (400 mg/kg BW) once a day for 12 weeks. The cells were analyzed using flow cytometry and tested statistically with one-way ANOVA with a = 0.05 by using SPSS 16.00 software. The results showed that mice with HFD treatment had a higher level of Lp-PLA2 (atherosclerosis marker) compared with the control group (data not shown). The level of IL-17 in the atherosclerotic mice in the D1 group was significantly depleted compared to the control group. Of the three doses above, D1 may be an optimal dose to minimize or prevent the damage from atherosclerosis than the other doses.

keywords:

The significance of Agaricus blazei as an immunomodulator of the level of IL-17 in Balb/C mice with atherosclerosis

Dicky Kurniawan Tontowiputro 1 , Djanggan Sargowo 1 , Askandar Tjokroprawiro 1 , Muhaimin Rifa’i 2

inflammation, atherosclerosis, high-fat diet, immunomodulator, Agaricus blazei

Dicky Kurniawan Tontowiputro

¹

,

Djanggan Sargowo

¹

,

Askandar Tjokroprawiro

¹

,

Muhaimin Rifa’i

²