Therapeutic strategies for brachial plexus injury

Hong Huang; Shuangqin Chen; Lin Wu; Shiying Dou; Qianlan Chen; Yihui Li; Zijian Xiao; Heng Wu; Shuangxi Chen

doi:10.5114/fn.2021.111996

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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4/2021
vol. 59

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abstract:

Research paper

Therapeutic strategies for brachial plexus injury

Hong Huang

¹

,

Shuangqin Chen

¹

,

Lin Wu

¹

,

Shiying Dou

¹

,

Qianlan Chen

¹

,

Yihui Li

¹

,

Zijian Xiao

¹

,

Heng Wu

¹

,

Shuangxi Chen

¹

The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, China

Folia Neuropathol 2021; 59 (4): 393-402

DOI: https://doi.org/10.5114/fn.2021.111996

Online publish date: 2021/12/30

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Brachial plexus avulsion (BPA), a severe acute peripheral nerve injury in adults, results in total loss of the motor function in the upper limb. Although immediate re-implantation surgery is widely performed to repair this lesion, the motor function cannot be fully restored. The main cause is that the growth velocity of axon is extremely slow in order to re-innervate the target muscles before atrophy develops. Therefore, the survival of spinal motoneurons (MNs) is considered to be a prerequisite for the recovery of motor function. The introduction of survival-proactive agents with anti-oxidative stress and anti-inflammation properties has emerged as a new approach to the motor function recovery following BPA. In the current review, we summarized the treatments of BPA in both mouse and rat models following re-implantation surgery. Furthermore, the pain treatment options following BPA were discussed.

keywords:

Therapeutic strategies for brachial plexus injury

Hong Huang 1 , Shuangqin Chen 1 , Lin Wu 1 , Shiying Dou 1 , Qianlan Chen 1 , Yihui Li 1 , Zijian Xiao 1 , Heng Wu 1 , Shuangxi Chen 1

brachial plexus avulsion (BPA), motoneurons (MNs), pain

Hong Huang

¹

,

Shuangqin Chen

¹

,

Lin Wu

¹

,

Shiying Dou

¹

,

Qianlan Chen

¹

,

Yihui Li

¹

,

Zijian Xiao

¹

,

Heng Wu

¹

,

Shuangxi Chen

¹