Time-related morphometric studies of neurofilaments in brain contusions

Mariusz Kobek; Zbigniew Jankowski; Janusz Szala; Zbigniew Gąszczyk-Ożarowski; Artur Pałasz; Rafał Skowronek

doi:10.5114/fn.2016.58915

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2016
vol. 54

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abstract:

Original paper

Time-related morphometric studies of neurofilaments in brain contusions

Mariusz Kobek

,

Zbigniew Jankowski

,

Janusz Szala

,

Zbigniew Gąszczyk-Ożarowski

,

Artur Pałasz

,

Rafał Skowronek

Folia Neuropathol 2016; 54 (1): 50-58

DOI: https://doi.org/10.5114/fn.2016.58915

Online publish date: 2016/03/31

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In forensic pathology age determination of injuries is of key importance. The purpose of the study was to analyze morphometrically changes in neurofilaments following the brain contusion and relate them to the length of the time of survival. To do this, the authors analyzed specimens of brains collected during medicolegal autopsies. According to the available literature, no such study involving material from deceased humans was conducted. The researched material was divided into nine subgroups (10 cases each) according to the time of death of persons: immediately at the crime site, 12 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days and 7 days after head trauma. Neurofilaments were immunohistochemically stained and evaluated quantitatively using the Met-Ilo computer application. The initial results were then analyzed statistically with the one way analysis of variance (ANOVA) and the least significant difference (LSD) tests. It was calculated that there are significant differences in numbers and area fractions of neurofilaments within 7 days after head trauma. It must be concluded that morphometric analysis of neurofilaments is a promising method but further studies are required.

keywords:

Time-related morphometric studies of neurofilaments in brain contusions

Mariusz Kobek , Zbigniew Jankowski , Janusz Szala , Zbigniew Gąszczyk-Ożarowski , Artur Pałasz , Rafał Skowronek

brain contusion, neurofilaments, morphometry, survival time

Mariusz Kobek

,

Zbigniew Jankowski

,

Janusz Szala

,

Zbigniew Gąszczyk-Ożarowski

,

Artur Pałasz

,

Rafał Skowronek