Transformation of IDH-wildtype glioblastoma to gliosarcoma with features of osteosarcoma

Paweł Sobczyk; Michał Sobstyl; Albert Acewicz; Joanna Rosa; Marta Grabiec; Wiesława Grajkowska

doi:10.5114/fn.2024.136020

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2024
vol. 62

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abstract:

Case report

Transformation of IDH-wildtype glioblastoma to gliosarcoma with features of osteosarcoma

Paweł Sobczyk

¹

,

Michał Sobstyl

¹

,

Albert Acewicz

²

,

Joanna Rosa

³

,

Marta Grabiec

⁴

,

Wiesława Grajkowska

⁵

Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland
Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
Department of Pathomorphology, Independent Public Clinical Hospital No. 2 PUM, Szczecin, Poland
Department of Translational Immunology and Experimental Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland
Department of Pathomorphology, Center of Postgraduate Medical Education, Warsaw, Poland

Folia Neuropathol 2024; 62 (1):96-101

DOI: https://doi.org/10.5114/fn.2024.136020

Online publish date: 2024/03/12

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Gliosarcoma (GS) is a rare variant of IDH-wildtype glioblastoma. It is classified as grade 4 in the latest WHO CNS classification of both glial and mesenchymal components. Gliosarcoma may arise de novo or secondary from glioblastoma. It occurs in up to 2% of patients diagnosed with glioblastoma. We present a case report of a 51-year-old patient who was initially diagnosed with glioblastoma multiforme, which transformed into secondary gliosarcoma with an osteosarcoma component 16 months after the initial diagnosis. We believe that increasing reporting of secondary gliosarcoma (sGS) will be helpful in understanding, diagnosing and providing more effective treatment for this cancer.

keywords:

Transformation of IDH-wildtype glioblastoma to gliosarcoma with features of osteosarcoma

Paweł Sobczyk 1 , Michał Sobstyl 1 , Albert Acewicz 2 , Joanna Rosa 3 , Marta Grabiec 4 , Wiesława Grajkowska 5

osteosarcoma, gliosarcoma, IDH-wildtype glioblastoma, secondary gliosarcoma, tumor transformation

Paweł Sobczyk

¹

,

Michał Sobstyl

¹

,

Albert Acewicz

²

,

Joanna Rosa

³

,

Marta Grabiec

⁴

,

Wiesława Grajkowska

⁵