Transmissible mink encephalopathy – review of the etiology

Beata Sikorska; Don Guiroy; Richard A. Bessen

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2009
vol. 47

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abstract:

Transmissible mink encephalopathy – review of the etiology

Beata Sikorska

,

Don Guiroy

,

Richard A. Bessen

Folia Neuropathol 2009; 47 (2): 195-204

Online publish date: 2009/06/26

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We review here the history, neuropathology, clinical picture and molecular data on transmissible mink encephalopathy (TME). This obscure disease is of utmost importance as it is plausible that it represents a transmission
of hidden bovine spongiform encephalopathy (BSE) to mink in the USA. Of special interest is the similarity of L-type of BSE and TME. Furthermore, experimental molecular studies showed the TME strain-specific in vitro conversion in a cell-free system. In addition, we show here for the first time confocal laser microscopy studies of co-localization of PrPd- amyloid plaques and GFAP-expressing astrocytes.

keywords:

Transmissible mink encephalopathy – review of the etiology

Beata Sikorska , Don Guiroy , Richard A. Bessen

prion, transmissible mink encephalopathy, TME, confocal laser microscopy

Beata Sikorska

,

Don Guiroy

,

Richard A. Bessen