eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
Share:
Send email
Share:
Original paper

Triptolide promotes nerve repair after cerebral ischemia reperfusion injury by regulating the NogoA/NgR/ROCK pathway

Huiyu Zhang
1
,
Minfang Guo
2
,
Peijun Zhang
2
,
Bingtao Mu
2
,
Zhenjun Bai
1
,
Liang Li
1
,
Jingwen Yu
2

  1. College of Traditional Chinese Medicine Health Service, Shanxi Datong University, Datong, China
  2. Institute of Brain Science, Shanxi Datong University, Datong, China
Folia Neuropathol 2023; 61:
DOI: https://doi.org/10.5114/fn.2023.133065
Online publish date: 2023/11/23
Article file
- Triptolide.pdf  [0.40 MB]
Get citation
 
PlumX metrics:
 
1. Chen SR, Dai Y, Zhao J, Lin L, Wang Y, Wang Y. A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F. Front Pharmacol 2018; 9: 104.
2. Cui Q, Zhang Y, Chen H, Li J. Rho kinase: A new target for treatment of cerebral ischemia/reperfusion injury. Neural Regen Res 2013; 8: 1180-1189.
3. Dehmelt L, Halpain S. The MAP2/Tau family of microtubuleassociated proteins. Genome Biol 2005; 6: 204.
4. Dore K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels HW, Malinow R. PSD-95 protects synapses from b-amyloid. Cell Rep 2021; 35: 109194.
5. Eslamboli A, Grundy RI, Irving EA. Timedependent increase in NogoA expression after focal cerebral ischemia in marmoset monkeys. Neurosci Lett 2006; 408: 89-93.
6. Feigin VL, Norrving B, Mensah GA. Global burden of troke. Circ Res 2017; 120: 439-448.
7. Fournier AE, GrandPre T, Strittmatter SM. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 2001; 409: 341-346.
8. Frey D, Laux T, Xu L, Schneider C, Caroni P. Shared and unique roles of CAP23 and GAP43 in actin regulation, neurite outgrowth, and anatomical plasticity. J Cell Biol 2000; 149: 1443-1454.
9. Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N. Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil. Int J Pharm 2016; 506: 129-137.
10. Hao M, Li X, Feng J, Pan N. Triptolide protects against ischemic stroke in rats. Inflammation 2015; 38: 1617-1623.
11. Hong L, Chen W, He L, Tan H, Peng D, Zhao G, Shi X, Wang L, Liu M, Jiang H. Effect of naoluoxintong on the NogoA/RhoA/ROCK pathway by down-regulating DNA methylation in MCAO rats. J Ethnopharmacol 2021; 281: 114559.
12. Huang S, Huang D, Zhao J, Chen L. Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling. Exp Ther Med 2017; 14: 905-912.
13. Jin XQ, Ye F, Zhang JJ, Zhao Y, Zhou XL. Triptolide attenuates cerebral ischemia and reperfusion injury in rats through the inhibition the nuclear factor kappa B signaling pathway. Neuropsychiatr Dis Treat 2015; 11: 1395-1403.
14. Kempf A, Schwab ME. Nogo-A represses anatomical and synaptic plasticity in the central nervous system. Physiology (Bethesda) 2013; 28: 151-163.
15. Kumar P, Moon LD. Therapeutics targeting Nogo-A hold promise for stroke restoration. CNS Neurol Disord Drug Targets 2013; 12: 200-208.
16. Li S, Carmichael ST. Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke. Neurobiol Dis 2006; 23: 362-373.
17. Li W, Yang Y, Hu Z, Ling S, Fang M. Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation. Front Neuroanat 2015; 9: 48.
18. Liao W, Huang X, Yin Y, Liu B, Zhu R. In vivo microdialysis with ultra performance liquid chromatography-mass spectrometry for analysis of tetramethylpyrazine and its interaction with borneol in rat brain and blood. Biomed Chromatogr 2018; 32: e4210.
19. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20: 84-91.
20. Merino P, Diaz A, Torre ER, Yepes M. Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse. J Biol Chem 2020; 295: 619-630.
21. Pan W, Xu Z. Triptolide mediates Wnt/beta-catenin signalling pathway to reduce cerebral ischemia-reperfusion injury in rats. Folia Neuropathol 2020; 58: 324-333.
22. Sekine Y, Lindborg JA, Strittmatter SM. A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration. J Biol Chem 2020; 295: 2175-2183.
23. Tang BL. Nogo-A and the regulation of neurotransmitter receptors. Neural Regen Res 2020; 15: 2037-2038.
24. Ugalde-Triviño L, Díaz-Guerra M. PSD-95: an effective target for stroke therapy using neuroprotective peptides. Int J Mol Sci 2021; 22: 12585.
25. Wälchli T, Pernet V, Weinmann O, Shiu JY, Guzik-Kornacka A, Decrey G, Yüksel D, Schneider H, Vogel J, Ingber DE, Vogel V, Frei K, Schwab ME. Nogo-A is a negative regulator of CNS angiogenesis. Proc Natl Acad Sci U S A 2013; 110: E1943-1952.
26. Wang J, Ni G, Liu Y, Han Y, Jia L, Wang Y. Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling. Drug Des Devel Ther, 2020; 14: 2775-2787.
27. Zhai ZY, Feng J. Constraint-induced movement therapy enhances angiogenesis and neurogenesis after cerebral ischemia/reperfusion. Neural Regen Res 2019; 14: 1743-1754.
28. Zhang B, Song C, Feng B, Fan W. Neuroprotection by triptolide against cerebral ischemia/reperfusion injury through the inhibition of NF-kB/PUMA signal in rats. Ther Clin Risk Manag 2016; 12: 817-824.
29. Zhao H, Liu ZD, Zhang YB, Gao XY, Wang C, Liu Y, Wang XF. NEP140 promotes myelin regeneration via upregulation of GAP43 and MAP2 expression after focal cerebral ischemia in rats. Mol Med Rep 2021; 24: 844.
30. Zheng Y, Zhang WJ, Wang XM. Triptolide with potential medicinal value for diseases of the central nervous system. CNS Neurosci Ther 2013; 19: 76-82.
31. Zhou C, Li Y, Nanda A, Zhang JH. HBO suppresses NogoA, NgR, or RhoA expression in the cerebral cortex after global ischemia. Biochem Biophys Res Commun 2003; 309: 368376.
Copyright: © 2023 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
FEATURED PRODUCTS
BOOKS
• Wprowadzenie do neurologopedii Wydanie II zaktualizowane
EVENTS
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.