Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease

Fatih Uzun; Mehmet Erturk; Huseyin Altug Cakmak; Ali Kemal Kalkan; Ibrahim Faruk Akturk; Ahmet Arif Yalcin; Begum Uygur; Umit Bulut; Kursat Oz

doi:10.5114/aic.2017.66184

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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abstract:

Original paper

Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease

Fatih Uzun

,

Mehmet Erturk

,

Huseyin Altug Cakmak

,

Ali Kemal Kalkan

,

Ibrahim Faruk Akturk

,

Ahmet Arif Yalcin

,

Begum Uygur

,

Umit Bulut

,

Kursat Oz

Adv Interv Cardiol 2017; 13, 1 (47): 32–38

DOI: https://doi.org/10.5114/aic.2017.66184

Online publish date: 2017/03/10

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AMA

Uzun F, Erturk M, Cakmak H, et al. Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2017;13(1):32-38. doi:10.5114/aic.2017.66184.

APA

Uzun, F., Erturk, M., Cakmak, H., Kalkan, A., Akturk, I.,  & Yalcin, A. et al. (2017). Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 13(1), 32-38. https://doi.org/10.5114/aic.2017.66184

Chicago

Uzun, Fatih, Mehmet Erturk, Huseyin Altug Cakmak, Ali Kemal Kalkan, Ibrahim Faruk Akturk, Ahmet Arif Yalcin,  and Begum Uygur et al. 2017. "Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 13 (1): 32-38. doi:10.5114/aic.2017.66184.

Harvard

Uzun, F., Erturk, M., Cakmak, H., Kalkan, A., Akturk, I., Yalcin, A., Uygur, B., Bulut, U.,  and Oz, K. (2017). Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 13(1), pp.32-38. https://doi.org/10.5114/aic.2017.66184

MLA

Uzun, Fatih et al. "Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 13, no. 1, 2017, pp. 32-38. doi:10.5114/aic.2017.66184.

Vancouver

Uzun F, Erturk M, Cakmak H, Kalkan A, Akturk I, Yalcin A et al. Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2017;13(1):32-38. doi:10.5114/aic.2017.66184.

Introduction: Inflammation and increased platelet activation play a crucial role in the initiation and progression of atherosclerosis. Platelet-to-lymphocyte ratio (PLR) has recently been reported as a new independent predictor for major adverse cardiovascular events in cardiovascular diseases.

Aim: To investigate the relation between PLR and cardiovascular mortality in patients with intermittent claudication or critical limb ischemia (CLI) or both.

Material and methods: In our retrospective study, 602 consecutive patients who were admitted to a large tertiary hospital with the diagnosis of symptomatic peripheral arterial occlusive disease (PAOD) were included. Patients were divided into two groups according to their PLR as follows: high PLR (PLR > 142) and low PLR (PLR ≤ 142) groups.

Results: During the follow-up period (median: 33.8 months (interquartile range: 21–45)), 131 deaths occurred out of 602 (21.8%) patients. Cardiovascular mortality was found to be significantly higher in the high PLR group compared to the low PLR group (31.6% vs. 17.2 %; p < 0.001). Even after adjustment for various risk factors, PLR > 142 and age were found to be independent predictors of long-term cardiovascular mortality in Cox regression analysis (hazard ratios (95% confidence interval): 1.03 (1.01–1.04) and 1.04 (1.02–1.06), p < 0.001 and p < 0.001, respectively).

Conclusions: Platelet-to-lymphocyte ratio, which is one of the parameters of routine complete blood count, reflects increased inflammatory status, platelet activation and aggregation. PLR is a cheap and readily available marker that has the ability to improve risk stratification provided by conventional risk scores in predicting long-term cardiovascular mortality in PAOD.

keywords:

Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease

Fatih Uzun , Mehmet Erturk , Huseyin Altug Cakmak , Ali Kemal Kalkan , Ibrahim Faruk Akturk , Ahmet Arif Yalcin , Begum Uygur , Umit Bulut , Kursat Oz

platelet-to-lymphocyte ratio, peripheral arterial occlusive disease, cardiovascular mortality

Fatih Uzun

,

Mehmet Erturk

,

Huseyin Altug Cakmak

,

Ali Kemal Kalkan

,

Ibrahim Faruk Akturk

,

Ahmet Arif Yalcin

,

Begum Uygur

,

Umit Bulut

,

Kursat Oz