Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance

Józef Krzysiek; Tomasz Milewicz; Krystyna Sztefko; Dorota Skucińska; Stanisław Radowicki

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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4/2006
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abstract:

Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia in postmenopausal women with normal and impaired glucose tolerance

Józef Krzysiek

,

Tomasz Milewicz

,

Krystyna Sztefko

,

Dorota Skucińska

,

Stanisław Radowicki

Prz Menopauz 2006; 4: 204–212

Online publish date: 2006/09/21

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AMA

Krzysiek J, Milewicz T, Sztefko K, Skucińska D, Radowicki S. Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance. Menopause Review/Przegląd Menopauzalny. 2006;5(4):204-212.

APA

Krzysiek, J., Milewicz, T., Sztefko, K., Skucińska, D.,  & Radowicki, S. (2006). Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance. Menopause Review/Przegląd Menopauzalny, 5(4), 204-212.

Chicago

Krzysiek, Józef, Tomasz Milewicz, Krystyna Sztefko, Dorota Skucińska,  and Stanisław Radowicki. 2006. "Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance". Menopause Review/Przegląd Menopauzalny 5 (4): 204-212.

Harvard

Krzysiek, J., Milewicz, T., Sztefko, K., Skucińska, D.,  and Radowicki, S. (2006). Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance. Menopause Review/Przegląd Menopauzalny, 5(4), pp.204-212.

MLA

Krzysiek, Józef et al. "Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance." Menopause Review/Przegląd Menopauzalny, vol. 5, no. 4, 2006, pp. 204-212.

Vancouver

Krzysiek J, Milewicz T, Sztefko K, Skucińska D, Radowicki S. Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia  in postmenopausal women with normal and impaired glucose tolerance. Menopause Review/Przegląd Menopauzalny. 2006;5(4):204-212.

Aim of study: Comparison between influence of transdermal continuous 17β-oestradiol combined with oral medroxyprogesterone (HRT) and oral simvastatin treatment on glycaemia and insulinaemia in postmenopausal women with normal and impaired glucose tolerance.
Materials and methods: 68 postmenopausal women were allocated to six groups. Groups A, B and C consisted of women with normal glucose tolerance, while groups D, E and F had women with impaired glucose tolerance. Group A 17 patients, group D 11 patients. Both groups received HRT. Groups B (10 women) and E (10 women) received simvastatin 20 mg orally. Groups C (10 women) and F (10 women) were controls.
Results: Basic fasting FSH, oestradiol, DHEAS, SHBG insulin and plasma levels were assessed as well as glucose and insulin during OGTT. HRT increased plasma insulin levels in women with normal glucose tolerance and had no such effect in women with IGT. Simvastatin had no effect on plasma insulin and glucose levels in postmenopausal women with normal glucose tolerance and reduced fasting insulin level in women with IGT.

keywords:

Influence of six months’ transdermal 17β -oestradiol administration combined with oral medroxyprogesterone or oral simvastatin treatment on glycaemia and insulinaemia in postmenopausal women with normal and impaired glucose tolerance

Józef Krzysiek , Tomasz Milewicz , Krystyna Sztefko , Dorota Skucińska , Stanisław Radowicki

17β-oestradiol, medroxyprogesterone, simvastatin, glucose, insulin, postmenopausal women

Józef Krzysiek

,

Tomasz Milewicz

,

Krystyna Sztefko

,

Dorota Skucińska

,

Stanisław Radowicki