miR-142-3p inhibits LPS-induced activation of NF-κB by targeting IRAK1 in colorectal cancer

Xu Zhiying; Peng Zhou; Ping Zhen Zhou; Jie Zhang; Le bo Cao; Xia Cui Liu; Jie Li

doi:10.5114/ceji.2013.39755

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2013
vol. 38

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abstract:

miR-142-3p inhibits LPS-induced activation of NF-κB by targeting IRAK1 in colorectal cancer

Xu Zhiying

,

Peng Zhou

,

Ping Zhen Zhou

,

Jie Zhang

,

Le bo Cao

,

Xia Cui Liu

,

Jie Li

(Centr Eur J Immunol 2013; 38 (4): 416-420)

DOI: https://doi.org/10.5114/ceji.2013.39755

Online publish date: 2013/12/30

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Inflammatory signals originating from colorectal cancer cells have a vital role in the development of colorectal cancer (CRC). microRNAs (miRNAs) have been demonstrated to be involved in the development and progression of CRC. miRNA-142-3p (miR-142-3p) has been reported to be a modulator of inflammatory signals. It has also been shown that miR-142-3p is downregulated in CRC and it acts to be a tumor suppressor. In the present study, interleukin-1 receptor-associated kinase 1 (IRAK1), a key mediator of NF-κB pathway, was identified as a direct target of miR-142-3p. It was also found that miR-142-3p repressed the activation of NF-κB signal induced by LPS in colorectal cancer cells, therefore reducing the expression of inflammatory cytokines, such as IL-6, IL-8, MCP-1, CCL5 and CSF-1. Thus, it is believed that miR-142-3p is a key component in the regulation of NF-κB activity and its anti-inflammatory role may contribute to its suppression of carcinogenesis of CRC.

keywords:

miR-142-3p inhibits LPS-induced activation of NF-κB by targeting IRAK1 in colorectal cancer

Xu Zhiying , Peng Zhou , Ping Zhen Zhou , Jie Zhang , Le bo Cao , Xia Cui Liu , Jie Li

colorectal cancer, non-coding RNA, inflammatory factors

Xu Zhiying

,

Peng Zhou

,

Ping Zhen Zhou

,

Jie Zhang

,

Le bo Cao

,

Xia Cui Liu

,

Jie Li