Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy)

Yuki Makai; Narihiko Hayashi; Izumi Koike; Hisashi Kaizu; Shoko Takano; Madoka Sugiura; Eiko Ito; Mizuki Sato; Hiroji Uemura; Masahiro Yao; Masaharu Hata

doi:10.5114/jcb.2018.79379

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy)

Yuki Makai

,

Narihiko Hayashi

,

Izumi Koike

,

Hisashi Kaizu

,

Shoko Takano

,

Madoka Sugiura

,

Eiko Ito

,

Mizuki Sato

,

Hiroji Uemura

,

Masahiro Yao

,

Masaharu Hata

J Contemp Brachytherapy 2018; 10, 5: 397–404

DOI: https://doi.org/10.5114/jcb.2018.79379

Online publish date: 2018/10/31

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AMA

Makai Y, Hayashi N, Koike I, et al. Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy). Journal of Contemporary Brachytherapy. 2018;10(5):397-404. doi:10.5114/jcb.2018.79379.

APA

Makai, Y., Hayashi, N., Koike, I., Kaizu, H., Takano, S.,  & Sugiura, M. et al. (2018). Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy). Journal of Contemporary Brachytherapy, 10(5), 397-404. https://doi.org/10.5114/jcb.2018.79379

Chicago

Makai, Yuki, Narihiko Hayashi, Izumi Koike, Hisashi Kaizu, Shoko Takano, Madoka Sugiura,  and Eiko Ito et al. 2018. "Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy)". Journal of Contemporary Brachytherapy 10 (5): 397-404. doi:10.5114/jcb.2018.79379.

Harvard

Makai, Y., Hayashi, N., Koike, I., Kaizu, H., Takano, S., Sugiura, M., Ito, E., Sato, M., Uemura, H., Yao, M.,  and Hata, M. (2018). Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy). Journal of Contemporary Brachytherapy, 10(5), pp.397-404. https://doi.org/10.5114/jcb.2018.79379

MLA

Makai, Yuki et al. "Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy)." Journal of Contemporary Brachytherapy, vol. 10, no. 5, 2018, pp. 397-404. doi:10.5114/jcb.2018.79379.

Vancouver

Makai Y, Hayashi N, Koike I, Kaizu H, Takano S, Sugiura M et al. Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy). Journal of Contemporary Brachytherapy. 2018;10(5):397-404. doi:10.5114/jcb.2018.79379.

Purpose
The aim of this analysis was to compare acute and late toxicities between low-dose-rate brachytherapy (LDR-BT) (110 Gy) in combination with 45 Gy in 25 fractions external beam radiation therapy (EBRT) and LDR-BT (160 Gy) alone for localized prostate cancer.

Material and methods
One hundred five consecutive patients with localized prostate cancer treated from May 2014 to May 2017 were included in this retrospective analysis. Sixty patients received combination therapy and 45 patients received BT monotherapy. The LDR-BT procedure was performed using 125I seeds.

Results
The median follow-up time was 28 months in both groups. Three-year effect rates were overall survival: 100% in both groups. The biochemical failure rate was 2.3% in the combination group and 0% in the monotherapy group (p = 0.373). No patients died during the study period. In both groups, almost all the patients experienced acute urethritis. There was a significant difference between the combination therapy group (8.3%) and BT monotherapy group (11.1%) in late genitourinary (GU) toxicities ≥ grade 2 (p = 0.035). Only 2 patients (3.3%) in the combination therapy group developed late ≥ grade 2 rectal hemorrhage. There were no significant differences between two groups in hematuria ≥ grade 2 (p = 0.068) or rectal hemorrhage ≥ grade 2 (p = 0.206).

Conclusions
To our knowledge, this is the first report to compare the GU and gastrointestinal toxicities between the combination therapy and BT monotherapy (160 Gy) for localized prostate cancer. Unexpectedly, there were more late GU toxicities (except for hematuria) in the BT monotherapy group.

keywords:

Acute and late toxicities in localized prostate cancer patients treated with low-dose 125I brachytherapy (110 Gy) in combination with external beam radiation therapy versus brachytherapy alone (160 Gy)

Yuki Makai , Narihiko Hayashi , Izumi Koike , Hisashi Kaizu , Shoko Takano , Madoka Sugiura , Eiko Ito , Mizuki Sato , Hiroji Uemura , Masahiro Yao , Masaharu Hata

low-dose-rate brachytherapy, prostate cancer, radiation therapy, toxicity

Yuki Makai

,

Narihiko Hayashi

,

Izumi Koike

,

Hisashi Kaizu

,

Shoko Takano

,

Madoka Sugiura

,

Eiko Ito

,

Mizuki Sato

,

Hiroji Uemura

,

Masahiro Yao

,

Masaharu Hata