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ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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1/2022
vol. 14
 
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abstract:
Original paper

CT-guided trans-sternal iodine-125 seeds implantation for masses in the anterior or middle mediastinum

Meng Wang
1
,
Feng Shi
2
,
Zhigang Zhou
1
,
Yao Cui
3
,
Kepu Du
1
,
Shuai Li
1
,
Tingting Liu
3
,
Yanlin Chen
3
,
Yadan Li
1
,
Fei Gao
1

  1. Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
  2. Department of Interventional Treatment, Guangdong Provincial People’s Hospital, Guangzhou, Guangdong, China
  3. Department of Nuclear Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
J Contemp Brachytherapy 2022; 14, 1: 35–42
DOI: https://doi.org/10.5114/jcb.2022.113548
Online publish date: 2022/02/18
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Introduction
The aim of this study was to explore the feasibility and clinical value of computed tomography (CT)-guided trans-sternal puncture to implant 125I seeds to treat masses in the anterior or middle mediastinum.

Material and methods
From September 2017 to December 2019, twenty patients with masses in the anterior or middle mediastinum were enrolled and treated with CT-guided trans-sternal 125I seeds implantation. Dosimetry parameters were compared between post-operative and pre-operative plans. Satisfaction rate of 125I seed distribution, complications, and local efficacy were evaluated.

Results
A total of 22 lesions were treated with 125I implantation in twenty patients, all procedures being successfully completed. The dosimetry parameters of the 20 patients immediately after surgery were as follows: mean D90 = 134.30 ±14.53 Gy; mean V90, V100, V150, and V200 were 96.10 ±1.55%, 92.69 ±1.93%, 66.86 ±7.53%, and 42.95 ±9.11%, respectively; mean conformity index (CI), external index (EI), and homogeneity index (HI) were 0.65 ±0.06, 40.79 ±13.72%, and 27.90 ±7.53%, respectively. The satisfaction rate of 125I seed distribution was 90%. The mean follow-up duration was 12 ±4.75 months (range, 4-24 months). The local control rates of 2 months, 6 months, and 1 year after surgery were 65.0%, 64.7%, and 53.8%, respectively. One patient had a small degree of pneumothorax, and one had hemoptysis after surgery.

Conclusions
CT-guided trans-sternal puncture plant 125I seeds for the treatment of masses in the anterior or middle mediastinum might serve as an alternative approach for treating specific mediastinal metastatic tumors.

keywords:

CT-guided, mediastinal metastasis, 125I seed, real-time planning, transdermal

  
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