eISSN: 2084-9885
ISSN: 1896-6764
Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology
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2/2017
vol. 12
 
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abstract:
Case report

Case report of limbic encephalitis with anti-NMDA antibodies

Katarzyna Ewa Osten-Sacken
,
Anna Jasińska-Mikołajczyk
,
Magda Katarzyna Malewska
,
Filip Rybakowski

Neuropsychiatria i Neuropsychologia 2017; 12, 2: 80–85
DOI: https://doi.org/10.5114/nan.2017.70637
Online publish date: 2017/10/12
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Limbic encephalitis (LE) is a disease known since 1960. At present, infectious and non-infectious cases are distinguished, and in the latter group paraneoplastic and non-paraneoplastic cases may be observed. Both are associated with the presence of an antibodies in serum and cerebrospinal fluid. A characteristic syndrome in LE is characterised by cognitive impairments, psychiatric disorders, and seizures. The onset of the disease is acute or subacute. EEG, and serologic and magnetic resonance imaging studies are important in diagnostics. The LE subtype with anti-NMDA receptors was described in 2007. It is probably the most common type of LE. This article describes a 57-year-old patient with a four-year history of memory disorders, sleep disturbance, and psychiatric symptoms. EEG abnormalities were observed, but MRI did not demonstrate the presence of lesions typical of LE. Finally, the presence of anti-NMDA antibodies and clinical picture led to the diagnosis of LE and its treatment.
keywords:

limbic encephalitis, anti-NMDA antibodies
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