Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) – case report

Anna Okruszko; Anna Baran; Dorota Zwierz-Gugała; Bożena Chodynicka; Iwona Flisiak

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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1/2013
vol. 100

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abstract:

Original paper

Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) – case report

Anna Okruszko

,

Anna Baran

,

Dorota Zwierz-Gugała

,

Bożena Chodynicka

,

Iwona Flisiak

Przegl Dermatol 2013, 100, 31–35

Online publish date: 2013/02/18

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Introduction. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a serious, potentially life-threatening syndrome with skin lesions, fever, internal organ involvement and eosinophilia.

Objective. To present the case of a woman with DRESS syndrome after the anticonvulsant drug lamotrigine.

Case report. A woman, 25 years old, suffering from epilepsy, was admitted to the hospital after the change of valpromic acid to lamotrigine, which caused generalized maculopapular eruptions and laboratory blood test abnormalities. After withdrawal of the causative drug and treatment with corticosteroids and antihistaminic preparations, skin lesions disappeared and the values of laboratory blood tests improved.

Conclusions. Due to the high rate of mortality (10%) in DRESS, a quick diagnosis is of crucial value. Most important is a detailed anamnesis, immediate withdrawal of the causative drug, and in severe cases therapy with systemic corticosteroids.

keywords:

Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) – case report

Anna Okruszko , Anna Baran , Dorota Zwierz-Gugała , Bożena Chodynicka , Iwona Flisiak

DRESS/DISH syndrome, lamotrigine, drug eruption

Anna Okruszko

,

Anna Baran

,

Dorota Zwierz-Gugała

,

Bożena Chodynicka

,

Iwona Flisiak