Genetic polymorphism of xenobiotic metabolizing enzymes in autoimmune connective tissue diseases

Małgorzata Barańska; Jadwiga Skrętkowicz

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2011
vol. 98

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abstract:

Review paper

Genetic polymorphism of xenobiotic metabolizing enzymes in autoimmune connective tissue diseases

Małgorzata Barańska

,

Jadwiga Skrętkowicz

Przegl Dermatol 2011, 98, 512–518

Online publish date: 2011/12/28

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Autoimmune connective tissue diseases are a clinically diverse group of chronic diseases, often serious in their consequences. Their pathogenesis is connected with the influence of environmental factors depending on individual genetic predisposition, among others, on detoxification enzymes. Genetic differences in the regulation, expression and activity of genes encoding phase I and phase II drug-metabolizing enzymes can be crucial factors in defining autoimmune disease susceptibility. In this review, current knowledge about polymorphism in several of these genes is summarized.

keywords:

Genetic polymorphism of xenobiotic metabolizing enzymes in autoimmune connective tissue diseases

Małgorzata Barańska , Jadwiga Skrętkowicz

biotransformation, genetic polymorphisms, systemic lupus erythematosus, systemic sclerosis

Małgorzata Barańska

,

Jadwiga Skrętkowicz