High-dose-rate skin brachytherapy with interstitial, surface, or a combination of interstitial and surface mold technique

Serhii Brovchuk; Sang-June Park; Zoia Shepil; Serhii Romanenko; Oleg Vaskevych

doi:10.5114/jcb.2022.114661

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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2/2022
vol. 14

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abstract:

Original paper

High-dose-rate skin brachytherapy with interstitial, surface, or a combination of interstitial and surface mold technique

Serhii Brovchuk

¹

,

Sang-June Park

²

,

Zoia Shepil

¹

,

Serhii Romanenko

¹

,

Oleg Vaskevych

¹

Radiotherapy Department, Kyiv Regional Oncology Dispensary, Kyiv, Ukraine
Department of Radiation Oncology, University of California Los Angeles, Los Angeles, USA

J Contemp Brachytherapy 2022; 14, 2: 107–114

DOI: https://doi.org/10.5114/jcb.2022.114661

Online publish date: 2022/03/17

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Purpose
In order to demonstrate capabilities of brachytherapy in skin cancer treatment, we reviewed clinical outcomes of patients with non-melanoma skin cancer (NMSC) treated with high-dose-rate brachytherapy (HDR-BT) at a single-institution.

Material and methods
A surface custom mold (SC), interstitial (IS), or a combination of IS and SC applicator (IS + SC) was used for treatment based on depth of tumor invasion. Contoured growth tumor volume plus a 0.5 cm margin for basal cell carcinomas (BCC) and a 1-1.5 cm margin for squamous cell carcinomas (SCC) was considered a target. A prescription dose of 41.6 Gy in 8 fractions was delivered to BCC, and 46.8 Gy in 9 fractions to SCC.

Results
From 2013 to 2018, a total of 751 NMSC patients (534 BCCs and 217 SCCs) were treated with HDR-BT (518 with IS, 225 with SC, and 8 with IS + SC technique). Thirty patients (4%) partially responded to treatment, and 721 patients (96%) had complete responses. Only 3 patients (0.4%) displayed local recurrences. Grade 1, 2, and 3 acute toxicities were observed in 28.0%, 46.7%, and 1.2% of patients, respectively. Grade 1, 2, and 3 late toxicities were observed in 3.3%, 1.3%, and 0.1% of cases. Cosmetic results were excellent in 79.9%, good in 17.8%, fair in 1.7%, and poor in 0.5% of patients.

Conclusions
HDR-BT using SC, IS, or IS + SC is an effective treatment for NMSC with good outcomes and cosmetic results in both BCC and SCC.

keywords:

High-dose-rate skin brachytherapy with interstitial, surface, or a combination of interstitial and surface mold technique

Serhii Brovchuk 1 , Sang-June Park 2 , Zoia Shepil 1 , Serhii Romanenko 1 , Oleg Vaskevych 1

brachytherapy, skin cancer, surface, HDR, interstitial

Serhii Brovchuk

¹

,

Sang-June Park

²

,

Zoia Shepil

¹

,

Serhii Romanenko

¹

,

Oleg Vaskevych

¹