eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2023
vol. 48
 
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abstract:
Experimental immunology

Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy

Jingjing Liu
1
,
Yingying Xu
1
,
Shijie Cheng
1
,
Chenfang Wang
1
,
Zhengyu Zhang
2

  1. Department of Endocrinology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
  2. Department of Endocrinology, Lishui Hospital of Traditional Chinese Medicine, Lishui, China
Cent Eur J Immunol 2023; 48 (4): 290-300
Online publish date: 2024/02/19
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Diabetic nephropathy (DN) is a major complication of diabetes. Interleukin-1 receptor-associated kinase 2 (IRAK2) has been implicated in various diseases. This study aimed to investigate the role of IRAK2 in DN progression and its association with inflammation and the nuclear factor-kappa B (NF-κB) signaling pathway. DN model mice were generated by intraperitoneal injection of streptozotocin. IRAK2 expression was upregulated in the DN model mice. IRAK2 knockdown increased weight and reduced blood glucose levels in DN model mice. In addition, IRAK2 downregulation improved glomerular morphology in DN mice. IRAK2 knockdown reduced the levels of kidney damage biomarkers (24-h urinary protein, urine albumin-creatinine ratio, and plasma creatinine) and inflammatory cytokines (IL-6, tumor necrosis factor [TNF]-α, TNF-1R, and TNF-2R). Moreover, IRAK2 activated the NF-κB signaling pathway in DN model mice. Overexpression of NF-κB exacerbated DN progression, and IRAK2 knockdown reversed these effects. IRAK2 promoted DN progression and inflammation by activating the NF-κB signaling pathway. These findings suggest that IRAK2 is a potential therapeutic target for DN treatment.
keywords:

interleukin-1 receptor-associated kinase 2, diabetic nephropathy, kidney injury, inflammation, NF-κB signaling pathway

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