Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy

Jingjing Liu; Yingying Xu; Shijie Cheng; Chenfang Wang; Zhengyu Zhang

doi:10.5114/ceji.2023.134721

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

4/2023
vol. 48

Send email

Copy url:

abstract:

Experimental immunology

Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy

Jingjing Liu

¹

,

Yingying Xu

¹

,

Shijie Cheng

¹

,

Chenfang Wang

¹

,

Zhengyu Zhang

²

Department of Endocrinology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
Department of Endocrinology, Lishui Hospital of Traditional Chinese Medicine, Lishui, China

Cent Eur J Immunol 2023; 48 (4): 290-300

DOI: https://doi.org/10.5114/ceji.2023.134721

Online publish date: 2024/02/19

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Liu J, Xu Y, Cheng S, Wang C, Zhang Z. Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy. Central European Journal of Immunology. 2023;48(4):290-300. doi:10.5114/ceji.2023.134721.

APA

Liu, J., Xu, Y., Cheng, S., Wang, C.,  & Zhang, Z. (2023). Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy. Central European Journal of Immunology, 48(4), 290-300. https://doi.org/10.5114/ceji.2023.134721

Chicago

Liu, Jingjing, Yingying Xu, Shijie Cheng, Chenfang Wang,  and Zhengyu Zhang. 2023. "Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy". Central European Journal of Immunology 48 (4): 290-300. doi:10.5114/ceji.2023.134721.

Harvard

Liu, J., Xu, Y., Cheng, S., Wang, C.,  and Zhang, Z. (2023). Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy. Central European Journal of Immunology, 48(4), pp.290-300. https://doi.org/10.5114/ceji.2023.134721

MLA

Liu, Jingjing et al. "Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy." Central European Journal of Immunology, vol. 48, no. 4, 2023, pp. 290-300. doi:10.5114/ceji.2023.134721.

Vancouver

Liu J, Xu Y, Cheng S, Wang C, Zhang Z. Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy. Central European Journal of Immunology. 2023;48(4):290-300. doi:10.5114/ceji.2023.134721.

PlumX metrics:

Diabetic nephropathy (DN) is a major complication of diabetes. Interleukin-1 receptor-associated kinase 2 (IRAK2) has been implicated in various diseases. This study aimed to investigate the role of IRAK2 in DN progression and its association with inflammation and the nuclear factor-kappa B (NF-κB) signaling pathway. DN model mice were generated by intraperitoneal injection of streptozotocin. IRAK2 expression was upregulated in the DN model mice. IRAK2 knockdown increased weight and reduced blood glucose levels in DN model mice. In addition, IRAK2 downregulation improved glomerular morphology in DN mice. IRAK2 knockdown reduced the levels of kidney damage biomarkers (24-h urinary protein, urine albumin-creatinine ratio, and plasma creatinine) and inflammatory cytokines (IL-6, tumor necrosis factor [TNF]-α, TNF-1R, and TNF-2R). Moreover, IRAK2 activated the NF-κB signaling pathway in DN model mice. Overexpression of NF-κB exacerbated DN progression, and IRAK2 knockdown reversed these effects. IRAK2 promoted DN progression and inflammation by activating the NF-κB signaling pathway. These findings suggest that IRAK2 is a potential therapeutic target for DN treatment.

keywords:

Interleukin-1 receptor-associated kinase 2 promotes inflammatory reactions by activating the nuclear factor kappa-B signaling pathway in diabetic nephropathy

Jingjing Liu 1 , Yingying Xu 1 , Shijie Cheng 1 , Chenfang Wang 1 , Zhengyu Zhang 2

interleukin-1 receptor-associated kinase 2, diabetic nephropathy, kidney injury, inflammation, NF-κB signaling pathway

Jingjing Liu

¹

,

Yingying Xu

¹

,

Shijie Cheng

¹

,

Chenfang Wang

¹

,

Zhengyu Zhang

²