Original article <br>

Ultrastructural pathology of cortical capillary pericytes in human traumatic brain oedema

Orlando J. Castejón

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2011
vol. 49

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abstract:

Original article
Ultrastructural pathology of cortical capillary pericytes in human traumatic brain oedema

Orlando J. Castejón

Folia Neuropathol 2011; 49 (3): 162-173

Online publish date: 2011/09/30

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In human traumatic brain oedema pericytes exhibit remarkable oedematous changes, increased vacuolar and vesicular transport, transient transpericytal channels, and tubular structures demonstrating pericyte brain barrier dysfunction. They show nuclear invaginations, actin and myosin-like filaments, and coupled interaction with endothelial cells through the macula occludens. Some pericytes display hypertrophic and necrotic changes, and phagocytic capacity. Hypertrophic pericytes induce basement membrane splitting. Degenerated pericytes exhibit lacunar enlargement of endoplasmic reticulum, dense osmiophilic bodies, glycogen granules, vacuolization, oedematous Golgi apparatus, and pleomorphic mitochondria. Certain micropinocytotic vesicles are orientated to the Golgi complex and multivesicular bodies, suggesting that pericytes play some role in oedema resolution.

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Original article Ultrastructural pathology of cortical capillary pericytes in human traumatic brain oedema

Orlando J. Castejón

pericytes, brain oedema, brain trauma, cerebral cortex, electron microscopy

Original article
Ultrastructural pathology of cortical capillary pericytes in human traumatic brain oedema