Placement of <sup>131</sup>Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note

Jacelyn Greenwald; Shoshana Taube; Menachem Z. Yondorf; Andrew Smith; Albert Sabbas; A. Gabriella Wernicke

doi:10.5114/jcb.2019.87230

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Case report

Placement of ¹³¹Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note

Jacelyn Greenwald

¹

,

Shoshana Taube

²

,

Menachem Z. Yondorf

²

,

Andrew Smith

²

,

Albert Sabbas

²

,

A. Gabriella Wernicke

^{2, 3}

Cornell University College of Arts and Sciences, Ithaca, New York, United States
Stich Radiation Oncology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, NY, United States
Department of Neurosurgery, Brain and Spine Center, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, NY, United States

J Contemp Brachytherapy 2019; 11, 4: 356–360

DOI: https://doi.org/10.5114/jcb.2019.87230

Online publish date: 2019/08/29

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AMA

Greenwald J, Taube S, Yondorf M, Smith A, Sabbas A, Wernicke A. Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note. Journal of Contemporary Brachytherapy. 2019;11(4):356-360. doi:10.5114/jcb.2019.87230.

APA

Greenwald, J., Taube, S., Yondorf, M., Smith, A., Sabbas, A.,  & Wernicke, A. (2019). Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note. Journal of Contemporary Brachytherapy, 11(4), 356-360. https://doi.org/10.5114/jcb.2019.87230

Chicago

Greenwald, Jacelyn, Shoshana Taube, Menachem Z. Yondorf, Andrew Smith, Albert Sabbas,  and A. Gabriella Wernicke. 2019. "Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note". Journal of Contemporary Brachytherapy 11 (4): 356-360. doi:10.5114/jcb.2019.87230.

Harvard

Greenwald, J., Taube, S., Yondorf, M., Smith, A., Sabbas, A.,  and Wernicke, A. (2019). Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note. Journal of Contemporary Brachytherapy, 11(4), pp.356-360. https://doi.org/10.5114/jcb.2019.87230

MLA

Greenwald, Jacelyn et al. "Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note." Journal of Contemporary Brachytherapy, vol. 11, no. 4, 2019, pp. 356-360. doi:10.5114/jcb.2019.87230.

Vancouver

Greenwald J, Taube S, Yondorf M, Smith A, Sabbas A, Wernicke A. Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note. Journal of Contemporary Brachytherapy. 2019;11(4):356-360. doi:10.5114/jcb.2019.87230.

Large brain metastases are presently treated with surgical resection and adjuvant radiotherapy. However, local control (LC) for large tumors decreases from over 90% to as low as 40% as the tumor/cavity increases. Intraoperative brachytherapy is one of the focal radiotherapy techniques, which offers a convenient option of starting radiation therapy immediately after resection of the tumor and shows at least an equivalent LC to external techniques. Our center has pioneered this treatment with a novel FDA-cleared cesium-131 (¹³¹Cs) radioisotope for the resected brain metastases, and published promising results of our prospective trial showing superior results from ¹³¹Cs application to the large tumors (90%). We report a 57-year-old male patient, with metastatic hypopharyngeal brain cancer. The patient presented with two metastases in the right frontal and right parietal lobes. Post-resection of these lesions resulted in a large total combined cavity diameter of 5.3 cm, which was implanted with ¹³¹Cs seeds. The patient tolerated the procedure well, with 100% local control and 0% radiation necrosis. This case is unique in demonstrating that the ¹³¹Cs isotope was not only a convenient option of treating two resected brain metastases in one setting, but also that this treatment option offered excellent long-term LC and minimal toxicity rates.

keywords:

Placement of 131Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note

Jacelyn Greenwald 1 , Shoshana Taube 2 , Menachem Z. Yondorf 2 , Andrew Smith 2 , Albert Sabbas 2 , A. Gabriella Wernicke 2, 3

cesium-131, 131Cs, brachytherapy, metastasis, radiation, radiotherapy

Placement of ¹³¹Cs permanent brachytherapy seeds in a large combined cavity of two resected brain metastases in one setting: case report and technical note

Jacelyn Greenwald

¹

,

Shoshana Taube

²

,

Menachem Z. Yondorf

²

,

Andrew Smith

²

,

Albert Sabbas

²

,

A. Gabriella Wernicke

^{2, 3}

cesium-131, ¹³¹Cs, brachytherapy, metastasis, radiation, radiotherapy