eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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1/2006
vol. 1
 
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abstract:

REVIEW ARTICLE
The diagnosis and medical management of gastroenteropancreatic neuroendocrine tumors (GEP NET)

Beata Kos-Kudła
,
Wanda Foltyn
,
Anna Zemczak
,
Bogdan Marek
,
Lucyna Siemińska
,
Dariusz Kajdaniuk

Przegl Gastroenterol 2006: 1, 1: 3–9
Online publish date: 2006/03/31
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Gastroenteropancreatic neuroendocrine tumors (GEP NET) constitute a heterogeneous group of neoplasms that are often associated with typical symptoms due to excessive and uncontrolled production of hormones and bioactive substances. The choice of treatment for GEP NET depends primarily on the pathologic differentiation and stage at diagnosis but also on the presence of symptoms related to hormonal secretion. Assessment of specific or nonspecific tumor markers offers high sensitivity in establishing the diagnosis and can also have prognostic significance. Imaging modalities include computed tomography and magnetic resonance imaging, scintigraphy with somatostatin analogs, endoscopic ultrasonography, endoscopy and substraction angiography. Surgery remains the first line therapy in NET. However these tumors are usually diagnosed at an advanced stage when cure cannot be achieved. Somatostatin analogs are important agents in the medical treatment of GEP NET. In selected cases of advanced, non-resectable disease, interferon alpha, radionuclides, ablation therapies and chemotherapy can be performed.
keywords:

gastroenteropancreatic neuroendocrine tumors, diagnostics, specific and nonspecific tumor markers, somatostatin-analogs, radionuclide therapy, chemotherapy
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