SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer

Valentina Lancellotta; Jose Luis Guinot; Bruno Fionda; Agata Rembielak; Alessandro Di Stefani; Stefano Gentileschi; Francesco Federico; Ernesto Rossi; Benjamin Guix; Artur Jan Chyrek; Arenas Meritxell; Silvia Villalba; Giuseppe Colloca; Nicola Dinapoli; Carlotta Masciocchi; Jacopo Lenkowicz; Nicola Capocchiano; Andrea Damiani; Vincenzo Valentini; Gyorgy Kovacs; Luca Tagliaferri

doi:10.5114/jcb.2020.94579

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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Original paper

SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer

Valentina Lancellotta

¹

,

Jose Luis Guinot

²

,

Bruno Fionda

¹

,

Agata Rembielak

^{3, 4}

,

Alessandro Di Stefani

^{5, 6}

,

Stefano Gentileschi

^{6, 7}

,

Francesco Federico

^{6, 8}

,

Ernesto Rossi

⁹

,

Benjamin Guix

¹⁰

,

Artur Jan Chyrek

¹¹

,

Arenas Meritxell

^{12, 13}

,

Silvia Rodriguez Villalba

¹⁴

,

Giuseppe Ferdinando Colloca

¹

,

Nicola Dinapoli

¹

,

Carlotta Masciocchi

¹

,

Jacopo Lenkowicz

¹

,

Nicola Dino Capocchiano

¹

,

Andrea Damiani

¹

,

Vincenzo Valentini

^{1, 6}

,

Gyorgy Kovacs

^{15, 16}

,

Luca Tagliaferri

¹

Fondazione Policlinico Universitario “A. Gemelli” IRCCS, UOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy
Department of Radiation Oncology, Foundation Instituto Valenciano de Oncologia (I.V.O.), Valencia, Spain
The Christie NHS Foundation Trust, Department of Clinical Oncology, Manchester, United Kingdom
The University of Manchester, Manchester, United Kingdom
Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Istituto di Dermatologia, Roma, Italy
Università Cattolica del Sacro Cuore, Roma, Italia
Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Dipartimento Scienze della Salute della Donna e del Bambino, Unità di Chirurgia Plastica, Roma, Italy
Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Institute of Pathology, Roma, Italy
Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Medical Oncology, Roma, Italy
Foundation IMOR, Department of Radiation Oncology, Barcelona, Spain
Greater Poland Cancer Centre, Brachytherapy Department, Poznań, Poland
Hospital Universitari Sant Joan de Reus, Radiation Oncology Department, Tarragona, Spain
Universitat Rovira i Virgili, Tarragona, Spain
Hospital Clinica Benidorm, Department of Radiation Oncology, Alicante, Spain
University of Lübeck/UKSH-CL, Interdisciplinary Brachytherapy Unit, Lübeck, Germany
Gemelli-INTERACTS, Università Cattolica del Sacro Cuore, Roma, Italy

J Contemp Brachytherapy 2020; 12, 2: 105–110

DOI: https://doi.org/10.5114/jcb.2020.94579

Online publish date: 2020/04/30

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AMA

Lancellotta V, Guinot J, Fionda B, et al. SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer. Journal of Contemporary Brachytherapy. 2020;12(2):105-110. doi:10.5114/jcb.2020.94579.

APA

Lancellotta, V., Guinot, J., Fionda, B., Rembielak, A., Di Stefani, A.,  & Gentileschi, S. et al. (2020). SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer. Journal of Contemporary Brachytherapy, 12(2), 105-110. https://doi.org/10.5114/jcb.2020.94579

Chicago

Lancellotta, Valentina, Jose Luis Guinot, Bruno Fionda, Agata Rembielak, Alessandro Di Stefani, Stefano Gentileschi,  and Francesco Federico et al. 2020. "SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer". Journal of Contemporary Brachytherapy 12 (2): 105-110. doi:10.5114/jcb.2020.94579.

Harvard

Lancellotta, V., Guinot, J., Fionda, B., Rembielak, A., Di Stefani, A., Gentileschi, S., Federico, F., Rossi, E., Guix, B., Chyrek, A., Meritxell, A., Villalba, S., Colloca, G., Dinapoli, N., Masciocchi, C., Lenkowicz, J., Capocchiano, N., Damiani, A., Valentini, V., Kovacs, G.,  and Tagliaferri, L. (2020). SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer. Journal of Contemporary Brachytherapy, 12(2), pp.105-110. https://doi.org/10.5114/jcb.2020.94579

MLA

Lancellotta, Valentina et al. "SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer." Journal of Contemporary Brachytherapy, vol. 12, no. 2, 2020, pp. 105-110. doi:10.5114/jcb.2020.94579.

Vancouver

Lancellotta V, Guinot J, Fionda B, Rembielak A, Di Stefani A, Gentileschi S et al. SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer. Journal of Contemporary Brachytherapy. 2020;12(2):105-110. doi:10.5114/jcb.2020.94579.

Purpose
The primary objective of the SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology is to define a specific terminological system to standardize data collection for non-melanoma skin cancer patients treated with brachytherapy (BT, interventional radiotherapy). Through ontological characterization of information, it is possible to find, isolate, organize, and integrate its meaning.

Material and methods
SKIN-COBRA is a standardized data collection consortium for non-melanoma skin patients treated with BT, including 8 cancer centers. Its ontology was firstly defined by a multicentric and multidisciplinary working group and evaluated by the consortium, followed by a multi-professional technical commission involving a mathematician, an engineer, a physician with experience in data storage, a programmer, and a software expert.

Results
Two hundred and ninety variables were defined in 10 input forms. There are 3 levels, with each offering a specific type of analysis: 1. Registry level (epidemiology analysis); 2. Procedures level (standard oncology analysis); 3. Research level (radiomics analysis). The ontology was approved by the technical commission and consortium, and an ad-hoc software system was defined to be implemented in the SKIN-COBRA consortium.

Conclusions
Large databases are natural extension of traditional statistical approaches, a valuable and increasingly necessary tool for modern healthcare system. Future analysis of the collected multinational and multicenter data will show whether the use of the system can produce high-quality evidence to support multidisciplinary management of non-melanoma skin cancer and utilizing this information for personalized treatment decisions.

keywords:

SKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer

brachytherapy, ontology, skin cancer