eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2023
vol. 48
 
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abstract:
Review paper

The pathogenesis and regulatory role of HIF-1 in rheumatoid arthritis

Han Li
1
,
Qi-Yang Wu
,
Xu-Heng Teng
1
,
Zhi-Peng Li
1
,
Meng-Ting Zhu
1
,
Chao-Jie Gu
1
,
Ben-Jia Chen
1
,
Qi-Qi Xie
1
,
Xin-Jing Luo
1

  1. Taizhou University, Taizhou, Zhejiang, China
Cent Eur J Immunol 2023; 48 (4): 338-345
DOI: https://doi.org/10.5114/ceji.2023.134217
Online publish date: 2024/01/08
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Rheumatoid arthritis (RA) is a prevalent autoimmune disease that involves the overgrowth and inflammation of synovial tissue, leading to the degeneration and impairment of joints. In recent years, numerous studies have shown a close relationship between the hypoxic microenvironment in joints and the occurrence and progression of RA. The main cause of the pathological changes in RA is widely believed to be the abnormal expression of hypoxia-inducible factor-1 (HIF-1) in joints. This paper describes and illustrates the structure and primary functions of HIF-1 and explains the main regulatory methods of HIF-1, including the PHDs/HIF-1/pVHL pathway, factor-inhibiting HIF (FIH), regulation of inflammatory cytokines, and the NF-B pathway. Furthermore, this paper discusses the mechanism of HIF-1 and its impact on inflammation, angiogenesis, and cartilage destruction in greater detail. We summarize previous research findings on the mechanism of HIF-1 and propose new potential treatments for RA based on the pathogenesis of HIF-1 in RA.
keywords:

angiogenesis, cartilage destruction, HIF-1, FLS, inflammation, rheumatoid arthritis
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