Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy

Juan Carlos Pari Salas; Kevin Aguirre Urviola; Paola Cynthia Smith Benavides; Digna Cristina Santos Flores; Albert Bedregal Cruz; Danny Giancarlo Apaza Véliz

doi:10.5114/jcb.2025.147944

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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1/2025
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abstract:

Original paper

Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy

Juan Carlos Pari Salas

^{1, 2}

,

Kevin Aguirre Urviola

²

,

Paola Cynthia Smith Benavides

²

,

Digna Cristina Santos Flores

²

,

Albert Bedregal Cruz

²

,

Danny Giancarlo Apaza Véliz

^{3, 4}

Universidad Católica de Santa María, Arequipa, Perú
Servicio de Radioterapia-Hospital Goyeneche de Arequipa, Perú
Universidad Nacional de San Agustín de Arequipa, Perú
Instituto Regional de Enfermedades Neoplásicas del Sur, Peru

J Contemp Brachytherapy 2025; 17, 1: 15–21

DOI: https://doi.org/10.5114/jcb.2025.147944

Online publish date: 2025/02/24

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AMA

Salas J, Urviola K, Smith Benavides P, Santos Flores D, Cruz A, Apaza Véliz D. Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy. Journal of Contemporary Brachytherapy. 2025;17(1):15-21. doi:10.5114/jcb.2025.147944.

APA

Salas, J., Urviola, K., Smith Benavides, P., Santos Flores, D., Cruz, A.,  & Apaza Véliz, D. (2025). Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy. Journal of Contemporary Brachytherapy, 17(1), 15-21. https://doi.org/10.5114/jcb.2025.147944

Chicago

Salas, Juan Carlos Pari, Kevin Aguirre Urviola, Paola Cynthia Smith Benavides, Digna Cristina Santos Flores, Albert Bedregal Cruz,  and Danny Giancarlo Apaza Véliz. 2025. "Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy". Journal of Contemporary Brachytherapy 17 (1): 15-21. doi:10.5114/jcb.2025.147944.

Harvard

Salas, J., Urviola, K., Smith Benavides, P., Santos Flores, D., Cruz, A.,  and Apaza Véliz, D. (2025). Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy. Journal of Contemporary Brachytherapy, 17(1), pp.15-21. https://doi.org/10.5114/jcb.2025.147944

MLA

Salas, Juan Carlos Pari et al. "Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy." Journal of Contemporary Brachytherapy, vol. 17, no. 1, 2025, pp. 15-21. doi:10.5114/jcb.2025.147944.

Vancouver

Salas J, Urviola K, Smith Benavides P, Santos Flores D, Cruz A, Apaza Véliz D. Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy. Journal of Contemporary Brachytherapy. 2025;17(1):15-21. doi:10.5114/jcb.2025.147944.

Purpose:
In cervical cancer, brachytherapy is a key component of multi-disciplinary treatment. Wide scale studies, such as EMBRACE, demonstrate benefits of volume-oriented and image-guided brachytherapy. However, MRI and CT are too expensive for health systems with scarce resources. The aim of the study was to assess whether ultrasound- and CT-based volumes of high-risk clinical target volume (HR-CTV) in organs at risk (OARs) as well as dose values in a given plan are comparable.

Material and methods:
Eighteen applications were evaluated. After CT scans, axial ultrasound images were acquired in 5 mm steps, serving as a secondary set. Post-prescription, HR-CTV, bladder, and rectum were contoured on ultrasound images. Image sets were compared using CT-based volumes as primary reference. Dice coefficient and Jaccard index were calculated. CT-based dosimetric plan was then compared with ultrasound-based volumes to determine D₉₀ HR-CTV, D_2cc bladder, and D_2cc rectum, and these were compared with CT-based values.

Results:
The mean dose differences between CT and ultrasound volumes for HR-CTV and D_2cc rectum were less than 5%, with the bladder slightly above 5%. Wilcoxon test showed no significant difference between the mean doses for CT and ultrasound. Dice coefficients indicated good to very good correlation for these volumes.

Conclusions:
Ultrasound-based volume acquisition appears comparable with CT volumetric acquisition in both dosimetric and volumetric terms. Further studies are needed to validate this technique, potentially offering a more affordable and feasible volume-based brachytherapy option for low-income health systems.

keywords:

Volumetric and dosimetric comparison of computed tomography- and trans-abdominal ultrasound-based volumes for image-guided cervix cancer brachytherapy

Juan Carlos Pari Salas 1, 2 , Kevin Aguirre Urviola 2 , Paola Cynthia Smith Benavides 2 , Digna Cristina Santos Flores 2 , Albert Bedregal Cruz 2 , Danny Giancarlo Apaza Véliz 3, 4

ultrasound, cervix, cancer, brachytherapy, 3D

Juan Carlos Pari Salas

^{1, 2}

,

Kevin Aguirre Urviola

²

,

Paola Cynthia Smith Benavides

²

,

Digna Cristina Santos Flores

²

,

Albert Bedregal Cruz

²

,

Danny Giancarlo Apaza Véliz

^{3, 4}