Nephrotoxicity of platinum derivatives in children – a review of the literature

This manuscript presents a review of the literature about nephrotoxicity of platinum derivatives, which are commonly used in paediatric oncology, such as cisplatin and carboplatin. It shows the incidence, pathomechanisms, risk factors, type and clinical features of the disorders. It presents differences in nephrotoxic effects of particular drugs, and describes possibilities of early detection and monitoring of clinical course and therapy. It emphasises the role of nephroprotective treatment.